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https://www.ncbi.nlm.nih.gov/pubmed/11741215
Receptor-targeted gene delivery via folate-conjugated polyethylenimine. Guo W(1), Lee RL. Author information: (1)Division of Pharmaceutics, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, USA. A novel synthetic gene transfer vector was evaluated for tumor cell-specific targeted gene delivery.Author: Wenjin Guo, Robert J. Lee
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751349/
Dec 10, 1999 · Folic acid is a high affinity ligand for the folate receptor that retains its binding affinity upon derivatization via its gamma carboxyl. Folate conjugation, therefore, presents a potential strategy for tumor-selective targeted gene delivery.Author: Wenjin Guo, Robert J. Lee
https://www.researchgate.net/publication/287932632_Targeted_Gene_Delivery_via_the_Folate_Receptor
Request PDF Targeted Gene Delivery via the Folate Receptor A novel synthetic gene transfer vector system is developed based on targeting to the folate receptor. The folate receptor is a ...
https://www.sciencedirect.com/science/article/pii/S016836591630551X
Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages. ... Our findings confirm that FA-3LM are taken up by activated macrophages via folate receptor mediated endocytosis and that their hydrogels release intact 3LM for efficient transfection of primary macrophages.Author: Mariam Mohammadi, Mariam Mohammadi, Ying Li, Daniel G. Abebe, Yuran Xie, Rima Kandil, Rima Kandil, T...
https://www.sciencedirect.com/science/article/pii/S1359644600015944
The structure of folic acid, the form of folate added to fortified foods and vitamin supplements, is shown in Fig. 1.Owing to the two carboxylate moieties positioned at the distal end of the folate molecule, passive membrane permeability at physiological temperature and pH is minimal.Author: Christopher P. Leamon, Philip S. Low
https://www.tandfonline.com/doi/abs/10.1517/17425247.5.3.309
Dec 07, 2012 · Targeted delivery via selective cellular markers can potentially increase the efficacy and reduce the toxicity of therapeutic agents. The folate receptor (FR) has two glycosyl phosphatidylinositol (GPI)-anchored isoforms, α and β. FR-α expression is frequently amplified in epithelial cancers, whereas FR-β expression is found in myeloid leukemia and activated macrophages associated with ...Author: Xiaobin Zhao, Hong Li, Robert J Lee
http://europepmc.org/articles/PMC2751349/
A novel synthetic gene transfer vector was evaluated for tumor cell-specific targeted gene delivery. The folate receptor is a tumor marker overexpressed in more than 90% of ovarian carcinomas and large percentages of other human tumors.
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