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https://www.rxlist.com/precedex-drug.htm#:~:text=Precedex%20should%20be%20administered%20by%20continuous%20infusion%20not,not%20necessary%20to%20discontinue%20Precedex%20prior%20to%20extubation.
https://theempulse.org/precedex-less-than-24hours/
Several case reports have described its use beyond the 24 hour recommended period without any major document adverse reactions. Thus the question arises, why is it only approved for 24 hours in the first place? Dexmedetomidine has a distribution half life of only 6 …
https://www.rxlist.com/precedex-drug.htm
Use of dexmedetomidine beyond 24 hours has been associated with tolerance and tachyphylaxis and a dose-related increase in adverse reactions [see ADVERSE REACTIONS]. Hepatic Impairment Since Precedex clearance decreases with severity of hepatic impairment, dose reduction should be considered in patients with impaired hepatic function [see ...
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021038s021lbl.pdf
• Prolonged exposure to dexmedetomidine beyond 24 hours may be ... • Precedex is not indicated for infusions lasting longer than 24 hours. • Precedex should be administered using a controlled infusion device. Page 3 of 24 Reference ID: 3326669 . 2.2 . Dosage Information .
https://www.drugs.com/pro/precedex.html
Use of dexmedetomidine beyond 24 hours has been associated with tolerance and tachyphylaxis and a dose-related increase in adverse reactions [see Adverse Reactions (6.1)]. Hepatic Impairment Since Precedex clearance decreases with severity of hepatic impairment, dose reduction should be considered in patients with impaired hepatic function [see ...
https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=548a88c0-afda-427e-75ac-5af0cfa2224c&name=548a88c0-afda-427e-75ac-5af0cfa2224c
Administer Precedex by continuous infusion not to exceed 24 hours. (1.1) Sedation of non-intubated patients prior to and/or during surgical and other procedures. ... Prolonged exposure to dexmedetomidine beyond 24 hours may be ... Precedex is not indicated for infusions lasting longer than 24 hours. Precedex should be administered using a ...
https://www.fda.gov/media/97355/download
The use of Precedex for procedural sedation in pediatric patients has not been evaluated. ... • Prolonged exposure to dexmedetomidine beyond 24 hours may be associated with tolerance and ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=548a88c0-afda-427e-75ac-5af0cfa2224c
Dexmedetomidine pharmacokinetic parameters after Precedex maintenance doses of 0.2 to 1.4 mcg/kg/hr for >24 hours were similar to the pharmacokinetic (PK) parameters after Precedex maintenance dosing for <24 hours in other studies. The values for clearance (CL), volume of distribution (V), and t 1/2 were 39.4 L/hr, 152 L, and 2.67 hours ...
http://labeling.pfizer.com/ShowLabeling.aspx?id=12157
Precedex (<6 hours). 5.6 Tolerance and Tachyphylaxis Use of dexmedetomidine beyond 24 hours has been associated with tolerance and tachyphylaxis and a dose-related increase in adverse reactions [see Adverse Reactions (6.1)]. 5.7 Hepatic Impairment Since Precedex clearance decreases with severity of hepatic impairment, dose reduction should be
https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206628s000lbl.pdf
Use of dexmedetomidine HCl beyond 24 hours has been associated with tolerance (reduction in response after longer duration; a higher dosage of dexmedetomidine HCl is required to produce the same effect that was obtained at a lower dosage); tachyphylaxis (a sudden decrease in response); and a dosage-related increase in adverse reactions.
https://pubmed.ncbi.nlm.nih.gov/20651314/
Purpose: The efficacy and safety of dexmedetomidine when used longer than the manufacturer-recommended 24 hours were evaluated. Summary: Dexmedetomidine is the newest agent available for use in the critical care setting to induce and maintain sedation and analgesia. However, concerns over efficacy and safety during prolonged administration are a limiting factor for use in this patient …
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