Precedex Use Over 24 Hours

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Precedex - FDA prescribing information, side effects and uses

    https://www.drugs.com/pro/precedex.html#:~:text=Precedex%20should%20be%20administered%20by%20continuous%20infusion%20not,not%20necessary%20to%20discontinue%20Precedex%20prior%20to%20extubation.
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Dexmedetomidine Infusion for More Than 24 Hours in ...

    https://pubmed.ncbi.nlm.nih.gov/15338124/
    Dexmedetomidine was an effective sedative and analgesic sparing drug in critically ill patients when used without a loading dose for longer than 24 h with predictable falls in blood pressure and HR. There was no evidence of cardiovascular rebound 24 h after abrupt cessation of infusion.

So, why is dexmedetomidine only approved for use for 24 hours?

    https://theempulse.org/precedex-less-than-24hours/
    However, with the slowly growing evidence of safely infusing dexmedetomidine for prolonged times, approval is being explored with the FDA for use for >24 hours 7. References: Shehabi, Y. et al, Dexmedetomidine infusion for more than 24 hours in critically ill patients: sedative and cardiovascular effects, Intensive Care Med, 2004 (30)2188-2196

Precedex - FDA prescribing information, side effects and …

    https://www.drugs.com/pro/precedex.html
    Precedex should be administered by continuous infusion not to exceed 24 hours. Precedex has been continuously infused in mechanically ventilated patients prior to extubation, during extubation, and post-extubation. It is not necessary to discontinue Precedex prior to extubation. Procedural Sedation

PrecedexTM For intravenous use. 1 INDICATIONS AND USAGE

    http://labeling.pfizer.com/ShowLabeling.aspx?id=12157
    Precedex™ is indicated for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting. Precedex should be administered by continuous infusion not to exceed 24 hours. Precedex has been continuously infused in mechanically ventilated patients prior to extubation, during

PRECEDEX Dosage and Administration …

    https://www.pfizermedicalinformation.com/en-us/precedex/dosage-admin
    Precedex is not indicated for infusions lasting longer than 24 hours. Precedex should be administered using a controlled infusion device.

Hospira, Inc. PRECEDEX- dexmedetomidine …

    https://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=548a88c0-afda-427e-75ac-5af0cfa2224c&name=548a88c0-afda-427e-75ac-5af0cfa2224c
    Precedex dosing should be individualized and titrated to desired clinical response. Precedex is not indicated for infusions lasting longer than 24 hours. Precedex should be administered using a controlled infusion device. 2.2 Dosage Information Table 1: Dosage Information INDICATION DOSAGE AND ADMINISTRATION Initiation of Intensive Care Unit Sedation

Precedex (dexmedetomidine) Safety and Drug …

    https://www.fda.gov/media/97355/download
    intubated patients prior to and/or during surgical and other procedures. Precedex is not indicated for infusions lasting longer than 24 hours and is not indicated for use in pediatrics.

Dexmedetomidine (Precedex) - Master Anesthesia

    https://masteranesthesia.com/dexmedetomidine-precedex/
    FDA approved for sedation for diagnostic procedures performed under monitored anesthesia care (MAC) and for short term sedation (less than 24 hours) of mechanically ventilated patients Electroconvulsive Therapy (ECT): Precedex has been shown to effectively lower blood pressure without affecting seizure duration

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