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https://www.sciencedirect.com/science/article/pii/S1359644615000641
Punctal plug: a medical device to treat dry eye syndrome and for sustained drug delivery to the eye ... several designs were developed either to enhance plug retention or to provide drug delivery or both . PPs are either semi-permanent or temporary depending on the material used for their preparation. ... ScienceDirect ® is a registered ...Author: Venkata K. Yellepeddi, Venkata K. Yellepeddi, Ravi Sheshala, Hannah McMillan, Chirag Gujral, David J...
https://www.ophthalmologytimes.com/ophthalmology/punctal-plug-drug-delivery-attractive-method-managing-glaucoma
Punctal plug-based delivery systems for sustained delivery of glaucoma medications represent new and versatile technology that is under development. The hope is it can help with the problem of patient compliance when managing mild-moderate glaucoma, said Marlene Moster, MD.
https://ois.net/punctal-plugs-for-sustained-delivery/
Nov 11, 2016 · The Evolute Punctal Plug Delivery System provides sustained ocular drug delivery that “is as good or better than what’s out there,” said Bob Butchofsky, Mati Therapeutics Inc.’s chief executive officer. For sustained drug delivery devices to be …
https://www.hindawi.com/journals/joph/2016/9312340/
An olopatadine punctal plug drug delivery system has been used in patients with allergic conjunctivitis but has not shown significant efficacy compared to placebo delivery system . There are reports on cyclosporine and moxifloxacin releasing punctal plug models being developed and used for delivery of these drugs [59, 60]. This approach can ...Author: Naz Jehangir, Greg Bever, S. M. Jafar Mahmood, Majid Moshirfar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834906/
Mar 08, 2012 · Punctal plug drug delivery systems are usually coated with a material that is impermeable to the drug and tear fluid on all sides except the head portion through which the drug is released into the tear film. The release of the drug from a punctal plug is controlled by drug diffusion to the tear fluid.Author: Nathan Gooch, Sarah A. Molokhia, Russell Condie, Randon Michael Burr, Bonnie Archer, Balamurali K. A...
https://www.aao.org/eyenet/article/novel-approaches-to-drug-delivery-2
/ Novel Approaches to Drug Delivery; Clinical Update. Novel Approaches to Drug Delivery. Written By: Miriam Karmel, Contributing Writer ... QLT reported that two phase 2 clinical studies demonstrated positive trends on the efficacy and safety of a latanoprost punctal plug delivery system in subjects with open-angle glaucoma and ocular ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051398/
Sep 01, 2010 · Generally, a punctal plug drug delivery system is coated with a material that is impermeable to the drug and tear fluid on all sides except the head portion, through which the drug is released into the tear film. The release of the drug from a punctal plug is controlled by drug diffusion from the polymeric core to the tear fluid.Author: Uday B Kompella, Rajendra S Kadam, Vincent Hl Lee
https://www.ondrugdelivery.com/therapy-without-drops-reality/
Mati has developed a completely non-invasive sustained-release platform by combining a novel punctal plug with a sustained release drug eluting core (see Figures 1 and 2). This platform is known as the Punctal Plug Delivery System (PPDS) or Evolute ®, as it will be known commercially.
https://patents.google.com/patent/US20050232972A1/en
A method and apparatus for administering an active agent such as a medicine to a subject, uses an ocular implant such as a punctal plug, to which the active agent has been applied. The implant is installed at the eye of the subject for administering the active agent via tissues of the eye.Author: Steven Odrich
https://medical-dictionary.thefreedictionary.com/punctal+plug
punctal plug: , punctum plug A small plastic device inserted into a tear duct to block the drainage of tears and treat dry eye syndromes. Synonym: lacrimal plug . See also: plug
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