Punctal Plug Drug Delivery System

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Punctal plug: a medical device to treat ... - ScienceDirect

    https://www.sciencedirect.com/science/article/pii/S1359644615000641
    Punctal plug: a medical device to treat dry eye syndrome and for sustained drug delivery to the eye Author links open overlay panel Venkata K. Yellepeddi 1 2 Ravi Sheshala 3 Hannah McMillan 4 Chirag Gujral 4 David Jones 4 Thakur Raghu Raj Singh 4Author: Venkata K. Yellepeddi, Venkata K. Yellepeddi, Ravi Sheshala, Hannah McMillan, Chirag Gujral, David J...

Mati: Punctal Plugs for Sustained Delivery Ophthalmology ...

    https://ois.net/punctal-plugs-for-sustained-delivery/
    Nov 11, 2016 · The Evolute Punctal Plug Delivery System provides sustained ocular drug delivery that “is as good or better than what’s out there,” said Bob Butchofsky, Mati Therapeutics Inc.’s chief executive officer. For sustained drug delivery devices to be successful, they must be easy to place and remove, must be cosmetically invisible but still easy to identify,…

Punctal plug drug delivery attractive method for managing ...

    https://www.ophthalmologytimes.com/ophthalmology/punctal-plug-drug-delivery-attractive-method-managing-glaucoma
    Punctal plug-based delivery systems for sustained delivery of glaucoma medications represent new and versatile technology that is under development. The hope is it can help with the problem of patient compliance when managing mild-moderate glaucoma, said Marlene Moster, MD.

US20050232972A1 - Drug delivery via punctal plug - Google ...

    https://patents.google.com/patent/US20050232972A1/en
    A method and apparatus for administering an active agent such as a medicine to a subject, uses an ocular implant such as a punctal plug, to which the active agent has been applied. The implant is installed at the eye of the subject for administering the active agent via tissues of the eye.Author: Steven Odrich

Safety/Efficacy of Nepafenac Punctal Plug Delivery System ...

    https://clinicaltrials.gov/ct2/show/NCT03496467
    Apr 12, 2018 · A punctal plug delivery system (PPDS) is being developed as a device that can deliver a sustained release of a drug to a specific eye. The PPDS is made up of a medical grade silicone punctal plug which holds an insert (core) that contains nepafenac, a nonsteroidal anti-inflammatory drug.

THERAPY WITHOUT DROPS: A REALITY - ONdrugDelivery

    https://www.ondrugdelivery.com/therapy-without-drops-reality/
    Mati has developed a completely non-invasive sustained-release platform by combining a novel punctal plug with a sustained release drug eluting core (see Figures 1 and 2). This platform is known as the Punctal Plug Delivery System (PPDS) or Evolute ®, as it will be known commercially.

Comprehensive Review of the Literature on Existing Punctal ...

    https://www.hindawi.com/journals/joph/2016/9312340/
    An olopatadine punctal plug drug delivery system has been used in patients with allergic conjunctivitis but has not shown significant efficacy compared to placebo delivery system . There are reports on cyclosporine and moxifloxacin releasing punctal plug models being developed and used for delivery of these drugs [59, 60]. This approach can ...Author: Naz Jehangir, Greg Bever, S. M. Jafar Mahmood, Majid Moshirfar

Mati Therapeutics - ONdrugDelivery

    https://www.ondrugdelivery.com/companies/mati-therapeutics-inc/
    Mati Therapeutics is developing its Punctal Plug Delivery System, a minimally invasive technology that can be used to introduce a variety of therapeutic agents to the eye through controlled, sustained release to the tear film. Initial target indications are glaucoma and ocular hypertension.

EyeWorld Novel drug delivery systems in glaucoma

    https://www.eyeworld.org/article-novel-drug-delivery-systems-in-glaucoma
    Punctal plug delivery system. A second novel method for long-term delivery of glaucoma medication involves incorporating a sustained-release depot of drug into a punctal plug. Dr. Lewis is participating in the development of just such a system in conjunction with QLT (Vancouver, British Columbia).

Ocular Drug Delivery for Glaucoma Management

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834906/
    Mar 08, 2012 · Punctal plug drug delivery systems are usually coated with a material that is impermeable to the drug and tear fluid on all sides except the head portion through which the drug is released into the tear film. The release of the drug from a punctal plug is controlled by drug diffusion to the tear fluid.Author: Nathan Gooch, Sarah A. Molokhia, Russell Condie, Randon Michael Burr, Bonnie Archer, Balamurali K. A...

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