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https://ois.net/punctal-plugs-for-sustained-delivery/
Nov 11, 2016 · The Evolute Punctal Plug Delivery System provides sustained ocular drug delivery that “is as good or better than what’s out there,” said Bob …
https://www.ondrugdelivery.com/companies/mati-therapeutics-inc/
Mati Therapeutics is developing its Punctal Plug Delivery System, a minimally invasive technology that can be used to introduce a variety of therapeutic agents to the eye through controlled, sustained release to the tear film. Initial target indications are glaucoma and ocular hypertension.
https://www.sciencedirect.com/topics/medicine-and-dentistry/punctal-plug
James N. Chang, in Handbook of Non-Invasive Drug Delivery Systems, 2010. 7.3.7 Others. In addition to the more popular delivery systems discussed above, several other approaches have also been investigated such as microspheres, iontophoresis, and punctal plugs, to name a few.
https://www.glaucoma.org/treatment/new-medication-delivery-systems-for-glaucoma.php
Around the eye: punctal (tear duct) plugs that release medication over time in a relatively non-invasive manner; New Horizons in Drug Delivery. On February 7, 2020, the Glaucoma Research Foundation hosted its annual Glaucoma 360 New Horizons …
https://bciq.biocentury.com/products/latanoprost_punctal_plug_delivery_system_(l-ppds)
Latanoprost punctal plug delivery system: Interim Phase II data Interim data from an ongoing, open-label Phase II trial in 47 patients showed that 44 µg latanoprost delivered via punctual plug produced a mean intraocular pressure (IOP) decrease of 3.5 mmHg from baseline at week...
https://www.reviewofoptometry.com/article/keep-on-plugging
Jan 15, 2012 · Currently, punctal plug delivery systems are being developed that can distribute a sustained time-release dose of glaucoma medication over a three-month period. 23 The Punctal Plug Delivery System (QLT Inc.) is designed to provide a consistent dose of …
https://clinicaltrials.gov/ct2/show/NCT01229982
A Study Evaluating the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
https://www.hindawi.com/journals/joph/2016/9312340/
Punctal and canalicular plugs are used in the management of various ocular conditions including dry eye disease and punctal stenosis as well as in ocular drug delivery. Although they are a relatively safe option, associated complications have been reported in the literature such as infection, allergic reaction, extrusion, and migration.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051398/
Sep 01, 2010 · Generally, a punctal plug drug delivery system is coated with a material that is impermeable to the drug and tear fluid on all sides except the head portion, through which the drug is released into the tear film. The release of the drug from a punctal plug is controlled by drug diffusion from the polymeric core to the tear fluid.
https://www.medicalnewstoday.com/articles/322021
Jun 04, 2018 · Punctal plugs are small medical devices that doctors can insert into the tear ducts in a procedure called punctal occlusion. The plugs may be temporary or …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800096/
Mar 07, 2016 · Punctal plugs used for drug delivery are made from various polymers and composed of an optional cap containing pores, optional outer shell that is impermeable to the drug and tears, cylindrical body containing the drug compound, and an optional unit for retaining the plug over a long period of time.
https://www.researchgate.net/publication/47790017_Ophthalmic_delivery_of_cyclosporin_A_by_punctal_plugs
Ophthalmic delivery of cyclosporin A by punctal plugs ... An olopatadine punctal plug drug delivery system has been used in patients with allergic conjunctivitis but has not shown significant ...
https://clinicaltrials.gov/ct2/show/NCT00820300
Jan 12, 2009 · A Safety Study of the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open Angle Glaucoma. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
https://www.ondrugdelivery.com/therapy-without-drops-reality/
This platform is known as the Punctal Plug Delivery System (PPDS) or Evolute ®, as it will be known commercially. The Evolute ® is inserted into the patient’s punctal …
https://www.healio.com/ophthalmology/cornea-external-disease/news/print/ocular-surgery-news/%7Bdf38cdbc-d391-495c-a9a6-452d088f8e95%7D/experts-five-tips-on-routine-use-of-punctum-plugs
Jun 01, 2000 · Officials at Odyssey Medical added that they recently debuted the Shuttle System, a punctal plug delivery system. According to the company, …
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