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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548250/
Jul 01, 2011 · Pulsatile drug delivery systems (PDDS) have attracted attraction because of their multiple benefits over conventional dosage forms. They deliver the drug at the right time, at the right site of action and in the right amount, which provides more benefit than …Author: Deepika Jain, Richa Raturi, Vikas Jain, Praveen Bansal, Ranjit Singh
http://www.iosrphr.org/papers/v2i2/ZL022338339.pdf
There is a constant need for new delivery systems that can provide increased therapeutic benefits to the patients. Pulsatile drug delivery is one such system (pulsincap) that, by delivering drug at the right time, right place, and in right amounts, holds
https://www.ijpsonline.com/articles/development-of-modified-pulsincap-drug-delivery-system-of-metronidazole-for-drug-targeting.html
All the formulations were assayed to determine drug content and the ability of the modified Pulsincap to provide colon-specific drug delivery was assessed by in vitro drug release studies in buffer pH 1.2 for 2 h, pH 7.4 (simulated intestinal fluid) for 3 h and pH 6.8 (stimulated colonic fluid) for 7 h.Author: Sindhu Abraham, Srinath
http://ijpsr.com/?action=download_pdf&postid=40824
Pulsincap drug delivery systems are mostly developed in capsule form. The lag time is controlled by a plug, which gets pushed away by swelling or erosion, and the drug is released. When this capsule comes in contact with the dissolution fluid, it swells; and after a lag time, the plug pushes ...
http://www.pharmtech.com/developing-modified-pulsincap-system
Nov 01, 2009 · This therapeutic effect is prolonged by continuously releasing the medication over an extended period of time after administering a single dose. The study objective was to explore the time-and pHdependent controlled drug delivery of DS using …
https://www.researchgate.net/publication/326535280_Formulation_and_Evaluation_of_Valsartan_Pulsincap_Drug_Delivery_System_for_Treatment_of_Hypertension
Pulsincap drug delivery system of Tramadol HCL is better option for these patients and also to impart the novelty to the existing formulation. In this type of drug delivery system, delayed release ...
https://innovareacademics.in/journal/ijpps/Vol6Issue5/7840.pdf
Formulation of pulsatile (modified pulsincap) drug delivery system: Preparation of modified pulsincap Equivalent to 10 mg drug granules were filled in the capsule bodies and plugged with hydrogel plug. The treated body and the cap of the capsules were sealed with a …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465138/
Pulsincap delivery combines advantages of pH-dependent and time-dependent colon targeting and overcomes the disadvantages of conventional method of colonic delivery (pH, time, and microflora-assisted delivery).Modified pulsincap™ dosage form consists of a formaldehyde-treated water-insoluble body and a water-soluble cap.
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