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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694965/
In contrast, the PTD-DRBD siRNA delivery approach described here fulfills many of the criteria for an efficient siRNA delivery system into primary cells. PTD-DRBD delivered siRNAs and induced RNAi responses in the entire population of three difficult to deliver primary cell types (T cells, HUVECs, and hESCs) in a rapid and non-cytotoxic fashion.Author: Akiko Eguchi, Akiko Eguchi, Akiko Eguchi, Bryan R Meade, Bryan R Meade, Yung-Chi Chang, Craig T Fred...
https://link.springer.com/protocol/10.1007/978-1-60761-919-2_24
Oct 12, 2010 · This chapter describes a recently reported delivery strategy, PTD–DRBD fusion protein siRNA delivery, where a double-stranded RNA-binding domain expressed as a fusion protein together with three TAT PTDs binds the siRNA, thus masking the …Author: Caroline Palm-Apergi, Akiko Eguchi, Steven F. Dowdy
https://www.researchgate.net/publication/47680674_PTD-DRBD_siRNA_delivery
This chapter describes a recently reported delivery strategy, PTD-DRBD fusion protein siRNA delivery, where a double-stranded RNA-binding domain expressed as a fusion protein together with three ...
https://www.researchgate.net/publication/41102783_Efficient_siRNA_delivery_by_novel_PTD-DRBD_fusion_proteins
DRBDs bind to siRNAs with high avidity, masking the siRNA's negative charge and allowing PTD-mediated cellular uptake. PTD-DRBD-delivered siRNA induced rapid RNAi in a …
https://www.frontiersin.org/articles/10.3389/fphys.2017.00256/full
Apr 28, 2017 · Keywords: insect pest, oral dsRNA delivery, gut nucleases, PTD-DRBD, dsRNA protection, RNA interference (RNAi) Citation: Gillet F-X, Garcia RA, Macedo LLP, Albuquerque EVS, Silva MCM and Grossi-de-Sa MF (2017) Investigating Engineered Ribonucleoprotein Particles to Improve Oral RNAi Delivery in Crop Insect Pests. Front.Author: François-Xavier Gillet, Rayssa A. Garcia, Leonardo L. P. Macedo, Erika V. S. Albuquerque, Maria C. M...
https://www.patentdocs.org/2009/08/efficient-delivery-of-sirna.html
In contrast, the PTD-DRBD siRNA delivery approach described here fulfills many of the criteria for and efficient siRNA delivery system for primary cells. . . . Because DRBDs bind to dsRNAs (siRNAs) independent of sequence composition, PTD-DRBD could in theory deliver any siRNA into cells.
https://www.cirm.ca.gov/our-progress/awards/tat-cell-permeable-protein-delivery-sirnas-epigenetic-programming-human
However, siRNAs are difficult to deliver into cells and current delivery approaches result in cytotoxicity, poor percentage of cells, changes in the overall transcription and biology of the cells, and even DNA damage. Recently, our labs have developed an approach to combine the advances in cell-permeable PTD peptides with siRNA delivery.
https://profiles.ucsd.edu/steven.dowdy
Steven Dowdy's profile, publications, research topics, and co-authors. Steven Dowdy's profile, publications, research topics, and co-authors. Powered by Altman Clinical and Translational Research Institute; ... PTD-DRBD siRNA delivery. Methods Mol Biol. 2011; 683:339-47. PMID: 21053141.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511671/
Delivery of small interfering RNA (siRNA) targeted to specific cell types is a significant challenge for the development of RNA interference-based therapeutics. Recently, PTD-DRBD, a double-stranded RNA binding domain (DRBD) fused to the TAT protein transduction ...Author: James C Geoghegan, Brian L Gilmore, Beverly L Davidson
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