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https://www.ncbi.nlm.nih.gov/pubmed/11532309
Sep 11, 2001 · Protein delivery from materials formed by self-selective conjugate addition reactions. Elbert DL(1), Pratt AB, Lutolf MP, Halstenberg S, Hubbell JA. Author information: (1)Institute for Biomedical Engineering and Department of Materials, Swiss Federal Institute of Technology and University of Zurich, Moussonstrasse 18, CH-8044, Zurich, Switzerland.Author: Donald L Elbert, Alison B Pratt, Matthias P Lutolf, Sven Halstenberg, Jeffrey A Hubbell
https://www.sciencedirect.com/science/article/pii/S0168365901003984
Protein delivery from materials formed by self-selective conjugate addition reactions 1. Introduction. The controlled delivery of proteins and other macromolecular drugs is... 2. Materials and methods. PEG-tetraacrylate was prepared from four-arm PEG, Mw =14 800 (10 g,... 3. Results. The rate of ...Author: Donald L Elbert, Alison B Pratt, Matthias P Lutolf, Sven Halstenberg, Jeffrey A Hubbell
https://infoscience.epfl.ch/record/81276
Protein delivery from materials formed by self-selective conjugate addition reactionsAuthor: Donald L Elbert, Alison B Pratt, Matthias P Lutolf, Sven Halstenberg, Jeffrey A Hubbell
https://www.researchgate.net/publication/11814464_Protein_delivery_from_materials_formed_by_self-selective_conjugate_addition_reactions
Protein delivery from materials formed by self-selective conjugate addition reactions Article in Journal of Controlled Release 76(1-2):11-25 · October 2001 with 121 Reads How we measure 'reads'
https://infoscience.epfl.ch/record/81276?of=HB
For some formulations, it was obsd. that about 65% of the incorporated protein was released with zero-order kinetics over a period of about 4 days. By changing the functionality of the cross-linker, the release of protein could even be delayed for about 4 days, followed by zero-order release.Author: Donald L Elbert, Alison B Pratt, Matthias P Lutolf, Sven Halstenberg, Jeffrey A Hubbell
http://core.ac.uk/display/12583668
The mechanism for release appeared to be a combination of slow dissoln. of protein in the presence of PEG and hindered diffusion of protein through the gel. The crosslinking of the gels was studied rheometrically, and the hydrolytic degrdn. of the gels was characterized by measuring the swelling of …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857543/
Proteins and peptides are very labile molecules so the coupling reactions should utilize only mild chemical conditions. The first generation of PEG derivatives were produced by attaching PEG activated via different chemistries to ε amino groups of lysine and included: (a) PEG succinimidyl carbonate,...Author: Dipak S. Pisal, Matthew P. Kosloski, Sathy V. Balu-Iyer
https://www.journals.elsevier.com/journal-of-controlled-release/news/jcr-topic-collection-protein-delivery/
Nov 29, 2010 · Issues in long-term protein delivery using biodegradable microparticles Volume 146, Issue 2, Pages 241-260 Mingli Ye, Sungwon Kim, Kinam Park Download this article to Reference Manager or EndNote. The mechanism of protein release from triglyceride microspheres Volume 147, Issue 2, Pages 202-210 A. Zaky, A. Elbakry, A. Ehmer, M. Breunig, A ...
https://www.sciencedirect.com/science/article/pii/S1369702112700913
Protein-based composite biomaterials can be formed into a wide range of biomaterials with tunable properties, including control of cell responses. The ability to tailor or tune the mechanical, surface and regeneration features provides a major advance for biomaterials in general, to address the growing range of medical material and device needs.Author: Xiao Hu, Peggy Cebe, Anthony S. Weiss, Fiorenzo Omenetto, David L. Kaplan
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