Protein Adsorption Drug Delivery

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Protein adsorption is required for stealth effect of poly ...

    https://www.nature.com/articles/nnano.2015.330
    Our results show that in addition to reducing protein adsorption, PEG, and now PEEPs, can affect the composition of the protein corona that forms around nanocarriers, and the presence of distinct ...Author: Susanne Schöttler, Greta Becker, Svenja Winzen, Tobias Steinbach, Kristin Mohr, Katharina Landfester...

Protein adsorption and cellular ... - PubMed Central (PMC)

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2259388/
    Protein adsorption on various materials has been widely studied and it has been found that, factors such as electrostatic interaction, hydrophobic interaction and specific chemical interactions between protein and the adsorbent play important roles. ... Targeted entry into cells is an important area of research in drug delivery and therapy [30 ...Author: Swanand Patil, Amanda Sandberg, Eric Heckert, William Self, Sudipta Seal

Studies of serum protein adsorption at phospholipid ...

    https://www.sciencedirect.com/science/article/pii/S0927775799001648
    1. Introduction. Serum protein adsorption is thought to play an important role in relation to clearance of intravenously administered colloidal drug carriers, such as liposomes, emulsions, solid lipid nanoparticles, etc. by the reticuloendothelial system (RES).Author: Martin Malmsten

PROTEIN ADSORPTION ON POLYMER PARTICLES P

    http://www.chem.ucla.edu/~wamozart/escs.pdf
    known can give some clues about protein adsorption on polymer particles. Biomedical applications of protein adsorption on poly-mer particles include the following: artificial tissues and organs, drug delivery systems, biosensors, solid-phase im-munoassays, immunomagnetic cell separations, and im-mobilized enzymes (1–5). FUNDAMENTALS

The impact of nanoparticle protein ... - PubMed Central (PMC)

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910943/
    Dec 11, 2015 · The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery. ... The modified NPs displayed a significant change in the degree and composition of plasma protein adsorption in vitro. Moreover, when the bare NPs were injected intravenously, their accumulation was higher in spleen than in the liver (ratio of ...Author: Claudia Corbo, Roberto Molinaro, Alessandro Parodi, Naama E Toledano Furman, Francesco Salvatore, En...

Protein adsorption on nanoparticles: model development ...

    https://iopscience.iop.org/article/10.1088/0953-8984/28/41/414019/pdf
    medical applications such as drug delivery [1], sensors [2] and disease diagnostics [3, 4]. When a nanoparticle enters a biolog-ical fluid such as blood, proteins adsorb on it spontaneously, forming a layer called the protein corona [5]. In essence, it is the protein corona, instead of the nanoparticle, that interactsAuthor: Qing Shao, Carol K Hall

The importance of interfaces in protein drug delivery ...

    https://www.researchgate.net/publication/51112818_The_importance_of_interfaces_in_protein_drug_delivery_-_Why_is_protein_adsorption_of_interest_in_pharmaceutical_formulations
    The importance of interfaces in protein drug delivery - Why is protein adsorption of interest in pharmaceutical formulations? ... Protein adsorption is widely studied; however, a more unified ...

BSA Nanoparticles for siRNA Delivery: Coating Effects on ...

    https://www.hindawi.com/journals/ijbm/2012/584060/
    Developing vehicles for the delivery of therapeutic molecules, like siRNA, is an area of active research. Nanoparticles composed of bovine serum albumin, stabilized <i >via</i> the adsorption of poly-L-lysine (PLL), have been shown to be potentially inert drug-delivery vehicles. With the primary goal of reducing nonspecific protein adsorption, the effect of using comb-type structures of poly ...Author: Haran Yogasundaram, Haran Yogasundaram, Markian Stephan Bahniuk, Markian Stephan Bahniuk, Harsh-Deep...

(PDF) Nanostructures for protein drug delivery

    https://www.researchgate.net/publication/284171142_Nanostructures_for_protein_drug_delivery
    We also discuss the importance of nanoparticle stabilization, as well as future opportunities and challenges in nanostructures for protein drug delivery. ... (physical entrapment or adsorption) or ...

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