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https://www.sciencedirect.com/topics/neuroscience/protein-aggregation
Protein aggregation can occur through chemical or physical degradation and is dependent on the thermodynamic stability of the protein's native state. The driving force behind protein aggregation is the reduction in free surface energy by the removal of hydrophobic residues from contact with the solvent.
https://www.cell.com/cell/fulltext/S0092-8674(15)00315-3
Apr 23, 2015 · Here, we describe a method for the efficient delivery of native proteins and other macromolecules, such as small RNAs, into primary cells. We discovered that a combination of small molecules drives the highly efficient intracellular delivery of native proteins, independent of any transduction peptide.Author: Diego S. D’Astolfo, Romina J. Pagliero, Anita Pras, Wouter R. Karthaus, Hans Clevers, Vikram Prasad,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857543/
Degradation of PLGA leads to accumulation of lactic and glycolic acids within the drug delivery device, thereby causing a significant reduction in pH of the surrounding microenvironment which can in turn facilitate denaturation of encapsulated protein, aggregation, and loss of activity. 103 True zero order release from the PLGA devices can also ...Author: Dipak S. Pisal, Matthew P. Kosloski, Sathy V. Balu-Iyer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063870/
Oct 23, 2010 · They can be formed during production, storage, shipment or delivery to the patient. Numerous stresses (e.g., temperature fluctuations, light, shaking, surfaces, pH adjustments, etc.) can induce protein aggregation during each of these stages (3,4). Aggregation can occur because of exposure to air-liquid or liquid-solid interfaces, e.g., during ...Author: John den Engelsman, Patrick Garidel, Ronald Smulders, Hans Koll, Bryan Smith, Stefan Bassarab, Andre...
https://www.sciencedirect.com/science/article/pii/S0169409X14002117
Protein inhalation is a delivery route which offers high potential for direct local lung application of proteins. Liquid formulations are usually available in early stages of biopharmaceutical development and nebulizers are the device of choice for atomization avoiding additional process steps like drying and enabling fast progression to clinical trials.Author: Sebastian P. Hertel, Gerhard Winter, Wolfgang Friess
https://www.genengnews.com/news/alzheimers-disease-protein-aggregation-prevented-by-cell-penetrating-peptides/
There are still some hurdles to be overcome, however. One significant obstacle to the successful application of most proteins as therapeutics is their poor delivery to target organs and cells.
http://www.biopharminternational.com/analyzing-protein-aggregation-biopharmaceuticals-0
Jan 01, 2015 · Causes of protein aggregation. BioPharm: What are the causes of protein aggregation in biologic formulations? Brown: Proteins have a natural propensity to aggregate due to the dynamic nature of their structure, which is held together by a combination of Van der Waals forces, hydrogen bonds, disulfide linkages, and hydrophobic interactions.Disruption of this delicate balance can expose internal ...
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