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https://www.annualreviews.org/doi/abs/10.1146%2Fannurev.pa.33.040193.002513
To concentrate a protein in the lumen of EVs, its interacting partner can be fused with ... Figure 5: Stem cell extracellular vesicles (EVs) for clinical applications. EVs are designed, manufactured, and quality controlled beforehand and stored as off-the-shelf medications to be infused in p...Author: Reza Oliyai, Valentino J. Stella
https://kuscholarworks.ku.edu/bitstream/handle/1808/92/fac12cit10.pdf;sequence=1
In using prodrugs to improve the formulation characteristics, transport. properties, and metabolic stability of peptides, one must consider the factors. influencing the chemical and physical stability of polypeptide as well as the. basic elements governing the enzymatic and biological barriers.
https://www.sciencedirect.com/science/article/abs/pii/0169409X9500110S
The most promising new approach appears to be the cyclization of the peptide backbone. It is my hope that this review will stimulate further research into the use of prodrugs for improved formulation and delivery of peptides and peptidomimetics.Author: Reza Oliyai
https://kuscholarworks.ku.edu/handle/1808/92
Prodrugs of peptides and proteins for improved formulation and delivery. View/ Open. fac12cit10.pdf (1.328Mb) Issue Date 1993. Author. ... Prodrugs of peptides and proteins for improved formulation and delivery. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 1993; 33: 52 …
http://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2019-12-3-69
The formulation design and delivery of protein drug delivery involves not only protection of protein/peptide from enzymatic degradation but also aid in enhancing its absorption without altering in biological activity. Hence there are several techniques involved for the successful delivery of proteins and peptides for their specific site of action.Author: L. Srinivas, V. Manikanta, M. Jaswitha
https://www.deepdyve.com/lp/annual-reviews/prodrugs-of-peptides-and-proteins-for-improved-formulation-and-6BCTjvVrbH
Prodrugs of Peptides and Proteins for Improved Formulation and Delivery Oliyai, Reza; Stella, Valentino J. 1993-04-01 00:00:00 This paper aims to review the existing literature on the use of prodrugs to circumvent some of the difficulties associated with the formulation, systemic delivery, and rapid clearance of peptide and protein therapeutic agents. Understanding the basic elements involved in effective delivery and formu lation of peptides …
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