We have collected information about Prodrugs Topical And Ocular Drug Delivery for you. Follow the links to find out details on Prodrugs Topical And Ocular Drug Delivery.
https://jamanetwork.com/journals/jamaophthalmology/fullarticle/640282
Prodrugs are reversible chemical derivatives that are hydrolyzed to release the active drug in an absorbing tissue or organ. This approach represents only a small, but significant, part of drug delivery and there is only one commercial product, Propine (Allergan Pharmaceuticals, Irvine, Calif; dipivalyl epinephrine) that uses this concept in the eye.Author: Joseph R. Robinson
https://www.amazon.com/Prodrugs-Topical-Delivery-Pharmaceutical-Sciences/dp/0824786297
Prodrugs: Topical and Ocular Drug Delivery (Drugs and the Pharmaceutical Sciences) 1st Edition by Kenneth B. Sloan (Editor)Author: Kenneth B. Sloan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407659/
Poor bioavailability of topically instilled drug is the major concern in the field of ocular drug delivery. Efflux transporters, static and dynamic ocular barriers often possess rate limiting factors for ocular drug therapy.Author: Megha Barot, Mahuya Bagui, Mitan R. Gokulgandhi, Ashim K. Mitra
https://www.worldcat.org/title/prodrugs-topical-and-ocular-drug-delivery/oclc/25281432
"Percutaneous Penetration Enhancement: Physicochemical Considerations and Implications for Prodrug Design, Richard H. Guy and Jonathan Hadgraft Functional Group Considerations in the Development of Prodrug Approaches to Solving Topical Delivery Problems, Kenneth B. Sloan Prodrugs for Dermal Delivery: Solubility, Molecular Size, and Functional Group Effects, Gerald B. Kasting, Ronald L. Smith, and Bradley D. Anderson A Computational Method for Predicting Optimization of Prodrugs …
https://www.wiley.com/en-us/Prodrugs+and+Targeted+Delivery%3A+Towards+Better+ADME+Properties-p-9783527326037
OCULAR DELIVERY USING PRODRUGS Introduction Criteria for an Ideal Ophthalmic Prodrug Anatomy and Physiology of the Eye Barriers to Ocular Drug Delivery Influx and Efflux Transporters on the Eye Transporter-Targeted Prodrug Approach Drug Disposition in Ocular Delivery Effect of Physiochemical Factors on Drug Disposition in Eye
https://www.liebertpub.com/doi/10.1089/jop.1986.2.67
The focus of this review is on recent developments in topical ocular drug delivery systems relative to their success in overcoming the constraints imposed by the eye and to the improvements that have yet to be made. In addition, this review attempts to place in perspective the importance of pharmacokinetic modeling…Author: Vincent H.L. Lee, Joseph R. Robinson
https://www.sciencedirect.com/science/article/pii/0169409X9500107I
Prodrug, soft-drug and the chemical delivery system (CDS) are the chemical approaches that improve ocular drug delivery by improving drug penetra- tion across the cornea. Prodrugs are pharmacologically inactive de- rivatives of drug molecules that require a chemi- cal or enzymatic transformation in order to release the active drug within the body [4].Author: Tomi Järvinen, Kristiina Järvinen
http://www.pharmtech.com/enhancing-topical-delivery-using-prodrugs
Dec 01, 2007 · It is now well-established that an adequate balance between lipid and water solubility is needed to improve topical delivery through the skin (because skin is a biphasic barrier). 4–6 Stability is also improved because phenolic drug molecules such as vitamin E and Naloxone are prone to aerial oxidation, however, manufacturing prodrugs ...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/prodrugs
Prodrugs refer to the drug delivery system where the active constituent is being released after metabolism of the drug. Usually in prodrugs, the drug and a chemical moiety is covalently linked, although sometimes it characterizes the salt derivative of the active drug.
https://www.researchgate.net/publication/26750185_Nanocarriers_in_Ocular_Drug_Delivery_An_Update_Review
Ocular drug delivery remains one of the most challenging tasks confronted with pharmaceutical practitioners due to the unique structure of the eye [59]. The anatomy and physiology of the eye make it highly impervious to xenobiotics (including drugs) [60].
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