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https://link.springer.com/chapter/10.1007%2F978-0-387-49785-3_16
Liver Targeted Drug Delivery Using HepDirectℳ Prodrugs. J Pharmacol Exp Ther 2004b; 308:554–560 CrossRef Google Scholar Fiume L, Bonino F, Mattioli A, Torrani-Cerenzia MR, Busi C, Brunetto MR, Verme G, and Chiaberge E. Inhibition of Hepatitis B Virus Replication by Vidarabine Monophosphate Conjugated with Lactosaminated Serum Albumin.Author: Mark D. Erion
https://www.researchgate.net/publication/226003914_Prodrugs_for_Liver-targeted_Drug_Delivery
Download Citation Prodrugs for Liver-targeted Drug Delivery The liver is the organ in the body primarily responsible for maintaining a continuous supply of glucose, lipids, and other important ...Author: Mark D. Erion
https://www.wiley.com/en-us/Prodrugs+and+Targeted+Delivery%3A+Towards+Better+ADME+Properties-p-9783527326037
OCULAR DELIVERY USING PRODRUGS Introduction Criteria for an Ideal Ophthalmic Prodrug Anatomy and Physiology of the Eye Barriers to Ocular Drug Delivery Influx and Efflux Transporters on the Eye Transporter-Targeted Prodrug Approach Drug Disposition in Ocular Delivery Effect of Physiochemical Factors on Drug Disposition in Eye
http://jpet.aspetjournals.org/content/312/2/554
Feb 01, 2005 · Here we show that a series of phosphate and phosphonate prodrugs, called HepDirect prodrugs, results in liver-targeted drug delivery following a cytochrome P450-catalyzed oxidative cleavage reaction inside hepatocytes.Author: Mark D. Erion, Paul D. van Poelje, Deidre A. MacKenna, Timothy J. Colby, Annika C. Montag, James M. ...
https://www.sciencedirect.com/science/article/pii/0169409X9500108J
Prodrugs Historically, from a drug delivery standpoint, prodrugs have been developed to circumvent a biologic barrier (e.g., low gastrointestinal per- meability or significant first-pass metabolism) in order to improve the systemic delivery of a drug.Author: Albert S. Kearney
https://onlinelibrary.wiley.com/doi/book/10.1002/9783527633166
Dec 15, 2010 · Jarkko Rautio is professor of pharmaceutical chemistry and head of the multidisciplinary Pharmaceutical and Medicinal Chemistry (PMC) research group at the School of Pharmacy, University of Eastern Finland (formerly University of Kuopio), where he received his PhD in pharmaceutical chemistry in 2000.
https://www.researchgate.net/publication/8372583_Liver-Targeted_Drug_Delivery_Using_HepDirect_Prodrugs
Here we show that a series of phosphate and phosphonate prodrugs, called HepDirect prodrugs, results in liver-targeted drug delivery following a cytochrome P450-catalyzed oxidative cleavage...
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