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https://www.pharmaceutical-journal.com/drug-delivery-progress-and-problems/20003039.fullarticle
There were three requirements: a mucoadhesive delivery system to anchor the drug to the front of the eye, a permeable conjunctiva and, most difficult of all, minimal drug clearance by the vasculature.
https://www.pharmacytimes.com/publications/issue/2013/may2013/transdermal-drug-delivery-systems-the-skinny-on-cutaneous-reactions
Transdermal drug delivery systems have grown in popularity, but side effects that include dermatitis and contact allergic reactions are possible.
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