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https://www.sciencedirect.com/science/article/pii/S0168365997001739
Chitosan is the second most plentiful biomass and is already known as a biocompatible, biodegradable, and low toxic material [16]. Chitosan is also considered to be a good candidate for the gene delivery system, since cationically charged chitosan can be complexed with …Author: K. Y. Lee, Ick Chan Kwon, Y. H. Kim, W. H. Jo, S. Y. Jeong
https://www.ncbi.nlm.nih.gov/pubmed/9685919
Feb 12, 1998 · Preparation of chitosan self-aggregates as a gene delivery system. Lee KY(1), Kwon IC, Kim YH, Jo WH, Jeong SY. Author information: (1)Biomedical Research Centre, Korea Institute of Science and Technology, Seoul, South Korea.Author: K. Y. Lee, Ick Chan Kwon, Y. H. Kim, W. H. Jo, S. Y. Jeong
https://koreauniv.pure.elsevier.com/en/publications/preparation-of-chitosan-self-aggregates-as-a-gene-delivery-system
Formation and characteristics of self-aggregates of hydrophobically modified chitosan were studied by fluorescence spectroscopy and dynamic light scattering method. The critical aggregation concentration (cac) of the self- aggregate was determined by measuring the fluorescence intensity of pyrene as a fluorescent probe.Author: K. Y. Lee, Ick Chan Kwon, Y. H. Kim, W. H. Jo, S. Y. Jeong
https://www.sciencedirect.com/science/article/pii/S0169409X01001983
In efficient gene delivery, plasmid DNA is introduced into target cells, transcribed and the genetic information ultimately translated into the corresponding protein. In order to achieve that goal, a number of obstacles have to be overcome by the gene delivery system . Transfection is hampered by (a) targeting the delivery system to the target cell, (b) transport through the cell membrane, (c) uptake and …Author: Gerrit Borchard
https://www.sciencedirect.com/science/article/pii/S0032386105008815
Preparation of chitosan self-aggregates Chitosan was hydrophobically modified with deoxycholic acid in the presence of EDC as previously reported. Chitosan was dissolved in 1% acetic acid solution and the same volume of methanol was added to the solution.Author: Kuen Yong Lee, Ick Chan Kwon, Won Ho Jo, Seo Young Jeong
https://www.sciencedirect.com/science/article/pii/S0142961205004229
For example, our group developed deoxycholic acid-modified chitosan derivatives that form nano-sized self-aggregates in an aqueous solution as potential carriers for the hydrophobic drug , and gene , . Although in vitro studies exhibited promising results for their use as the drug delivery system, clinical trials were not successful since the insoluble nature of chitosan at pH 7.4 led to the precipitation in a …Author: Jae Hyung Park, Jae Hyung Park, Seunglee Kwon, Minsu Lee, Hesson Chung, Ji-Hyun Kim, Yoo-Shin Kim, R...
https://pubs.acs.org/doi/abs/10.1021/bc015510c
Nov 03, 2001 · Abstract. Precise control of the size and structure is one critical design parameter of micellar systems for drug delivery applications. To control the size of self-aggregates, chitosan was depolymerized with various amounts of sodium nitrite, and hydrophobically modified with deoxycholic acid to form self-aggregates in aqueous media.Author: Young Hyo Kim, Se Hoon Gihm, Chong Rae Park, Kuen Yong Lee, Kuen Yong Lee, Tae Woo Kim, Ick Chan Kwo...
https://www.sciencedirect.com/science/article/pii/S0927775707008515
These micellar or nanoparticles can be used as peptide delivery system, gene delivery system, or drug delivery system , . As one of the water-soluble derivatives of chitoson, succinyl-chitosan (SCCHS) has favourable properties as a drug carrier such as biocompatibility, low …Author: Weiping Sui, Yuanhao Wang, Shuli Dong, Yanjing Chen
https://www.researchgate.net/publication/282266534_Chitosan
In conclusion, this study provides insights into the use of chitosan as a gene delivery system. It emphasises that chitosan is a nontoxic alternative to other cationic polymers and it forms a ...
https://link.springer.com/chapter/10.1007/4-431-27879-6_6
Chitosan possesses many favorable characteristics for use as a gene delivery system. However, further improvements in the structure and function of this system, such as optimization of chitosan (molecular weight or DDA), chemical modification using functional groups, and formation of ternary complexes, are still necessary.
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