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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863989/
Antibiotic prophylaxis at the time of non-laboring cesarean delivery significantly reduces the risks of postpartum endometritis and wound infection. Introduction Mothers delivering by cesarean are at a 5 to 30-fold increased risk for postpartum infection-related complications, compared to …Author: Mara J. Dinsmoor, Sharon Gilbert, Mark B. Landon, Dwight J. Rouse, Catherine Y. Spong, Michael W. Va...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950587/
May 18, 2016 · Antimicrobial prophylaxis is used routinely for pre-, intra- and post-operative caesarean section. One of the most important risk factors for postpartum infection is caesarean delivery. Caesarean section shows a higher incidence of infection than vaginal delivery. It is complicated by surgical site infections, endometritis or urinary tract infection.Author: Ronghua Liu, Lin Lin, Dujuan Wang
https://www.acog.org/en/Clinical/Clinical%20Guidance/Practice%20Bulletin/Articles/2018/09/Use%20of%20Prophylactic%20Antibiotics%20in%20Labor%20and%20Delivery
The following practices related to cesarean delivery include preoperative skin and vaginal cleansing, weight-based dosage for cefazolin antibiotic prophylaxis, the addition of adjunctive azithromycin antibiotic prophylaxis, and antibiotic selection and dosage for women with a penicillin allergy.
https://sites.utexas.edu/phr-residencies/files/2018/10/20181102-Gonzales-Antibiotic-prophylaxis-and-treatment-of-cesarean-sections.pdf
1960s: Burke showed giving abx prior to wound contamination decreased rate of infection 1992: SSIs increase hospital stay by 10+ days and add $3152 per case 2005-2010: Studies supporting abx prophylaxis timed prior to incision are safer and more beneficial than after cord clamping Today: CD rates at an all-time high.
https://www.obgproject.com/2018/08/29/acog-guidance-antibiotic-prophylaxis-during-labor-and-delivery/
Cesarean Section Antibiotic Prophylaxis . Prophylaxis Recommendation . All cesarean deliveries unless already on equivalent broad spectrum coverage . Administer within 60 minutes before the start of the cesarean delivery ; If not possible (e.g., emergency surgery) Administer as soon as possible after the incision; Weight Adjusted Dosing (IV route)
https://www.uptodate.com/contents/cesarean-delivery-preoperative-planning-and-patient-preparation
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https://www.uptodate.com/contents/cesarean-delivery-preoperative-planning-and-patient-preparation?search=cesarean%20section&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2
Antibiotic Prophylaxis for Cesarean Delivery - When Broader Is Better. N Engl J Med 2016; 375:1284. Ragusa A, Svelato A. Adjunctive Azithromycin Prophylaxis for Cesarean Delivery.
https://medicine.utah.edu/obgyn/postgraduate-course/docs/handout-antibiotics-for-cesarean-wound-complications.pdf
Cesarean Prophylaxis and IAI • If the patient is already receiving broad spectrum antibiotics for another indication (IAI, pyelo, etc), additional cefazolin is not necessary • One additional dose of chosen regimen should be given after cesarean • PLUS Clindamycin 900 mg IV or metronidazole 500 mg IV for at least one dose ACOG CO 712, 2017
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