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https://www.sciencedirect.com/science/article/pii/0014579393811772
It is envisaged that large molecular weight polysialic acids would be suita- ble for the delivery of one or more molecules of small molecular weight drugs and peptides. Shorter chain pol- ysialic acids, on the other hand (derived by autohy- drolysis of long-chain molecules), could be used to coat large proteins as well as drug delivery systems such as liposomes.Author: G. Gregoriadis, B. McCormack, Z. Wang, R. Lifely
https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/0014-5793%2893%2981177-2
the polysialic acid used, increased by deacylation of their phospholipid moiety, decreased with shorter chain derivatives and appeared to be dose independent. A model drug (fluorescein) covalently coupled to a polysialic acid was found to assume the half-life of its carrier.Author: G. Gregoriadis, B. McCormack, Z. Wang, R. Lifely
https://www.ncbi.nlm.nih.gov/pubmed/8422917
Jan 11, 1993 · A model drug (fluorescein) covalently coupled to a polysialic acid was found to assume the half-life of its carrier. Results suggest that intact or deacylated polysialic acids and shorter chain derivatives can be used to augment the half-lives of drugs, small peptides, proteins and drug delivery systems in the blood circulation, thus prolonging their pharmacological action.Author: G. Gregoriadis, B. McCormack, Z. Wang, R. Lifely
https://www.sciencedirect.com/science/article/abs/pii/0014579393811772
A model drug (fluorescein) covalently coupled to a polysialic acid was found to assume the half-life of its carrier. Results suggest that intact or deacylated polysialic acids and shorter chain derivatives can be used to augment the half-lives of drugs, small peptides, proteins and drug delivery systems in the blood circulation, thus prolonging their pharmacological action.Author: G. Gregoriadis, B. McCormack, Z. Wang, R. Lifely
https://core.ac.uk/display/82094171
A model drug (fluorescein) covalently coupled to a polysialic acid was found to assume the half-life of its carrier. Results suggest that intact or deacylated polysialic acids and shorter chain derivatives can be used to augment the half-lives of drugs, small peptides, proteins and drug delivery systems in the blood circulation, thus prolonging their pharmacological actionAuthor: G. Gregoriadis, B. McCormack, Z. Wang, R. Lifely
https://www.future-science.com/doi/full/10.4155/tde.13.153
When the potential for immunogenicity is combined with a lack of degradability, PEG is a particularly poor choice for drug delivery in the treatment of immune system disorders and/or diseases that require long term treatment, such as rheumatoid arthritis.Author: Rebecca A Bader, Patricia R Wardwell
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