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https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201000076
The major limiting factor for those channels is the lack of efficient, nontoxic, and nonimmunogenic gene‐delivery systems. 77 Cationic lipid formulations and cationic polymer‐based nonviral vectors stand for safer and less costly alternatives to viral vectors. However, the frequent need for additional co‐lipids and the polydispersity of polymeric compounds complicates evaluation of dose scheduling and …Author: Carmen Ortiz Mellet, Juan M. Benito, José M. García Fernández
http://onlinelibrary.wiley.com/doi/10.1002/chem.201000076/abstract
Preorganization of functional elements onto macromolecular platforms has the potential to allow control of the self‐assembling behavior of discrete architectures to produce nanometric objects that can be programmed to complex, compact, deliver, and release plasmid DNA in a target cell.
https://pubs.rsc.org/en/content/articlelanding/2009/ob/b903635k#!
Gene delivery systems based on the β-cyclodextrin scaffold have been synthesized by combining the copper(I)-catalyzed azide-alkyne coupling (“click chemistry”) and an efficient acylation method of the secondary hydroxyls; molecular flexibility, charge density and hydrophobic-hydrophilic balance are critical parameters that can be fine-tuned by the ...
https://www.researchgate.net/publication/44639996_Preorganized_Macromolecular_Gene-Delivery_Systems
In fact, together with some cyclodextrin-based gene-delivery systems which appeared nearly simultaneously [72] and despite several examples of cationic lipids and amphiphiles, to the best of our ...
https://core.ac.uk/display/36046620
Preorganization of functional elements onto macromolecular platforms has the potential to allow control of the self-assembling behavior of discrete architectures to produce nanometric objects that can be programmed to complex, compact, deliver, and release plasmid DNA in a target cell.This work was supported by the Spanish Ministerio de Ciencia e Innovación (MCINN, contract numbers CTQ2006 …Author: Carmen Ortiz Mellet, Juan M. Benito, José M. García Fernández
https://digital.csic.es/handle/10261/36374
May 28, 2010 · Preorganization of functional elements onto macromolecular platforms has the potential to allow control of the self-assembling behavior of discrete architectures to produce nanometric objects that can be programmed to complex, compact, deliver, and release plasmid DNA in a target cell.Author: Carmen Ortiz Mellet, Juan M. Benito, José M. García Fernández
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