Preorganized Macromolecular Gene-Delivery Systems

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Preorganized, Macromolecular, Gene‐Delivery Systems ...

    https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201000076
    The major limiting factor for those channels is the lack of efficient, nontoxic, and nonimmunogenic gene‐delivery systems. 77 Cationic lipid formulations and cationic polymer‐based nonviral vectors stand for safer and less costly alternatives to viral vectors. However, the frequent need for additional co‐lipids and the polydispersity of polymeric compounds complicates evaluation of dose scheduling and …Author: Carmen Ortiz Mellet, Juan M. Benito, José M. García Fernández

Preorganized, Macromolecular, Gene‐Delivery Systems ...

    http://onlinelibrary.wiley.com/doi/10.1002/chem.201000076/abstract
    Preorganization of functional elements onto macromolecular platforms has the potential to allow control of the self‐assembling behavior of discrete architectures to produce nanometric objects that can be programmed to complex, compact, deliver, and release plasmid DNA in a target cell.

Preorganized macromolecular gene delivery systems ...

    https://pubs.rsc.org/en/content/articlelanding/2009/ob/b903635k#!
    Gene delivery systems based on the β-cyclodextrin scaffold have been synthesized by combining the copper(I)-catalyzed azide-alkyne coupling (“click chemistry”) and an efficient acylation method of the secondary hydroxyls; molecular flexibility, charge density and hydrophobic-hydrophilic balance are critical parameters that can be fine-tuned by the ...

Preorganized, Macromolecular, Gene-Delivery Systems ...

    https://www.researchgate.net/publication/44639996_Preorganized_Macromolecular_Gene-Delivery_Systems
    In fact, together with some cyclodextrin-based gene-delivery systems which appeared nearly simultaneously [72] and despite several examples of cationic lipids and amphiphiles, to the best of our ...

Preorganized, Macromolecular, Gene-Delivery Systems

    https://core.ac.uk/display/36046620
    Preorganization of functional elements onto macromolecular platforms has the potential to allow control of the self-assembling behavior of discrete architectures to produce nanometric objects that can be programmed to complex, compact, deliver, and release plasmid DNA in a target cell.This work was supported by the Spanish Ministerio de Ciencia e Innovación (MCINN, contract numbers CTQ2006 …Author: Carmen Ortiz Mellet, Juan M. Benito, José M. García Fernández

Preorganized, Macromolecular, Gene-Delivery Systems

    https://digital.csic.es/handle/10261/36374
    May 28, 2010 · Preorganization of functional elements onto macromolecular platforms has the potential to allow control of the self-assembling behavior of discrete architectures to produce nanometric objects that can be programmed to complex, compact, deliver, and release plasmid DNA in a target cell.Author: Carmen Ortiz Mellet, Juan M. Benito, José M. García Fernández

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