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https://www.sciencedirect.com/science/article/pii/B9781782420330000092
At the same time, multimodal porous structure and interconnectivity of pores make them promising candidates for site-specific drug delivery. The use of porous hydroxyapatite as a drug delivery system could result in a dual effect: the ability to interact with the bone tissues at the same time ensuring increased drug efficiency, controlled release, and site-specific delivery.Author: D. Loca, J. Locs, A. Dubnika, V. Zalite, L. Berzina-Cimdina
https://www.researchgate.net/publication/282740320_Porous_hydroxyapatite_for_drug_delivery
Porous hydroxyapatite for drug delivery. The disadvantages of systemic drug therapy are that only a small fraction of any given dose actually reaches the surgical site, producing low-therapeutic tissue levels. An alternative approach is based on the use of implantable delivery tools, able to release the active substance in a controlled way.
https://www.researchgate.net/publication/46010451_Porous_bovine_hydroxyapatite_for_drug_delivery
Biomaterials derived from natural sources have considerable interest in human health care. This study reports a simple method of designing a bone drug delivery system using porous bovine...
https://www.sciencedirect.com/science/article/pii/S0928493116300546
Porous hollow hydroxyapatite microspheres (PHHMs) are the promising biomaterials, owing to their excellent biocompatibility, biodegradability and bioactivity. PHHMs have been used as drug controlled carriers due to their advantages such as large drug loading capacity, nanochannels for drug loading and release and high specific surface area.Author: Wen Lai, Cen Chen, Xiaoyuan Ren, In-Seop Lee, Guohua Jiang, Xiangdong Kong
https://www.sciencedirect.com/science/article/pii/S0927776519302127
Interconnected porous scaffolds are widely used in the applications of tissue repair and regeneration. Sustained local delivery of drugs and growth factors around the implanted scaffolds could accelerate the growth of cells and contribute to the regeneration of damaged tissues.Author: Shangsi Chen, Yufei Shi, Yun Luo, Jun Ma
https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.201904766
Abstract Hydroxyapatite(HA) are widely used in the field of drug delivery, especially nano‐HA and porous HA. However, there are few reports on the use of inverse opal HA as drug carrier.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846463/
Various drug delivery systems, such as liposomes, micelles, emulsions, polymeric micro/nanoparticles have been showing great promise in controlled and targeted drug delivery. Among these systems porous materials are emerging as a new category of host/guest systems[3–6].
https://www.sciencedirect.com/science/article/pii/S1468699606002348
Owing to their physicochemical and biological properties, porous HAs have been proven as a potential candidate for bone drug delivery system . This type of drug delivery system, via use of a bioactive matrix, can release a therapeutic agent in situ to produce an anti-infection action associating the osteoconductivity of materials.Author: I. Sopyan, M. Mel, S. Ramesh, K.A. Khalid
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