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https://www.sciencedirect.com/science/article/pii/S1471489206001172
Molecular Trojan horses for peptide drug delivery to the brain. A peptidomimetic mAb is a receptor-specific mAb that binds an exofacial epitope on the BBB RMT system, and this binding allows the mAb to undergo RMT across the BBB by ‘piggy backing’ on the endogenous peptide transport system.Author: William M Pardridge
https://www.ncbi.nlm.nih.gov/pubmed/16839816
Molecular Trojan horses for blood-brain barrier drug delivery. ... (BBB) in vivo. A new solution to the brain drug delivery problem is the genetic engineering of recombinant fusion proteins. The therapeutic peptide or protein drug is fused to a molecular Trojan horse, which is a second peptide or peptidomimetic monoclonal antibody that binds a ...Author: William M Pardridge
https://www.researchgate.net/publication/6568807_Molecular_Trojan_horses_for_blood-brain_barrier_drug_delivery
Molecular Trojan horses for blood-brain barrier drug delivery Article · Literature Review (PDF Available) in Discovery medicine 6(34):139-43 · September 2006 with 1,013 Reads How we measure 'reads'
http://www.genomenewsnetwork.org/articles/12_03/trojan_horse.shtml
The vast majority of drugs designed to treat brain disease never make it to the brain. That’s because the blood vessels to the brain are made of cells that are so tightly packed that they form a physical barrier that lets very few molecules slip through. Now researchers have designed an ingenious strategy dubbed a “molecular Trojan horse” for ferrying molecules across the blood-brain ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539316/
INTRODUCTION. The blood-brain barrier (BBB) is the bottleneck in brain drug development and is the single most important factor limiting the future growth of neurotherapeutics. 1 The BBB problem is illustrated in Figure 1, which is a whole body autoradiogram of a mouse sacrificed 30 min after intravenous injection of radiolabeled histamine, a small molecule of only ∼100 Da in molecular mass.
https://www.sciencedirect.com/science/article/pii/S1359644606004363
Genetic engineering of molecular Trojan horses for BBB delivery in humans. ... in conscious rats after intravenous injection of a biotinylated vasoactive intestinal peptide analog coupled to a blood-brain barrier drug delivery system. J. Pharmacol. Exp. Ther., 279 (1996), pp. 77-83.Author: William M. Pardridge
https://link.springer.com/article/10.1007/s40259-017-0248-z
Oct 24, 2017 · Biologics are potential new therapeutics for many diseases of the central nervous system. Biologics include recombinant lysosomal enzymes, neurotrophins, decoy receptors, and therapeutic antibodies. These are large molecule drugs that do not cross the blood–brain barrier (BBB). All classes of biologics have been tested, without success, in clinical trials of brain disease over the last 25 ...Author: William M. Pardridge
https://www.tandfonline.com/doi/abs/10.1517/17425247.2014.952627
Dec 14, 2017 · Blood–brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody. William M Pardridge ArmaGen Technologies, Inc., 26679 Agoura Road, ... The TfRMAb acts as a molecular Trojan horse to ferry the fused biologic drug into the brain via receptor-mediated transport on the endogenous BBB TfR.Author: William M Pardridge
https://www.deepdyve.com/lp/elsevier/molecular-trojan-horses-for-blood-brain-barrier-drug-delivery-GtZkPs0mwT
Oct 01, 2006 · Molecular Trojan horses for blood–brain barrier drug delivery Molecular Trojan horses for blood–brain barrier drug delivery Pardridge, William M 2006-10-01 00:00:00 Peptides and recombinant proteins such as neurotrophins, enzymes and monoclonal antibodies, have not been developed as new drugs for the brain because these large molecule drugs do not cross the brain capillary wall, which ...
https://www.mdpi.com/1999-4923/6/4/557/pdf
Abstract: The blood–brain barrier acts as a physical barrier that prevents free entry of blood-derived substances, including those intended for therapeutic applications. The development of molecular Trojan horses is a promising drug targeting technology that allows for …Author: Julia V. Georgieva, Dick Hoekstra, Inge S. Zuhorn
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