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https://web.stanford.edu/group/pawender/drug-delivery.html
Molecular Transporters for Drug and Probe Delivery The unmet need for effective delivery technologies for drugs and diagnostics comprises one of the most exciting areas of opportunity at the interface of chemistry, biology, materials science and medicine.
https://pubs.acs.org/doi/10.1021/ja0275109
Oct 18, 2002 · Molecular transporters have the ability to deliver drugs and probe molecules into cells and tissues irrespective of their physical properties. We now report the design, synthesis, and biological evaluation of a new family of molecular transporters, guanidinylated oligocarbamates that enable exceptionally efficient uptake into cells and tissues.Author: Paul A. Wender, Jonathan B. Rothbard, Theodore C. Jessop, Erik L. Kreider, Bryan L. Wylie
https://www.sciencedirect.com/science/article/pii/S0169409X17303137
Nanomaterials and molecular transporters to overcome the bacterial envelope barrier: Towards advanced delivery of antibiotics ... Liposomes started to be extensively investigated already in the 1970s for drug delivery into mammalian cells [203,204], but only recently liposomes attracted interest to carry antibacterial drugs.Author: Rita S. Santos, Céu Figueiredo, Nuno F. Azevedo, Kevin Braeckmans, Stefaan C. De Smedt
https://pubs.acs.org/doi/full/10.1021/jm0105676
Short oligomers of arginine, either alone or when conjugated to therapeutic agents or large biopolymers, have been shown to cross readily a variety of biological barriers (e.g., lipid bilayers and epithelial tissue). Molecular modeling suggests that only a subset of the side chain guanidinium groups of these transporters might be required for transport involving contact with a common surface ...Author: Jonathan B. Rothbard, Erik Kreider, Christopher L. VanDeusen, Lee Wright, Bryan L. Wylie, Paul A. We...
https://onlinelibrary.wiley.com/doi/10.1002/cbic.200600171
Molecular Transporters: Synthesis of Oligoguanidinium Transporters and Their Application to Drug Delivery and Real‐Time Imaging. Elena A. Goun. Stanford University, Department of Chemistry Stanford, CA, 94305, USA. Search for more papers by this author. Thomas H. Pillow.Author: Elena A. Goun, Thomas H. Pillow, Lisa R. Jones, Jonathan B. Rothbard, Paul A. Wender
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123947/
Aug 04, 2014 · 4. Molecular Transporters for Overcoming Efflux-Mediated MDR. A distinct strategy for overcoming Pgp-mediated efflux and associated MDR is based on the use of drug delivery agents that modify the mechanism of cellular entry of a drug and thus avoid Pgp export.Author: Jessica R. Vargas, Erika Geihe Stanzl, Nelson N. H. Teng, Paul A. Wender
https://onlinelibrary.wiley.com/doi/full/10.1002/cbic.200600171
Molecular Transporters: Synthesis of Oligoguanidinium Transporters and Their Application to Drug Delivery and Real‐Time Imaging. ... One bioinspired strategy for crossing biological barriers is based on the use of molecular transporters, the focus of this minireview and our studies Stanford.Author: Elena A. Goun, Thomas H. Pillow, Lisa R. Jones, Jonathan B. Rothbard, Paul A. Wender
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494002/
Aug 29, 2012 · This review will discuss both the principals of BBB drug transport, and strategies for the reengineering of drugs to enable BBB transport. The classical approaches to drug delivery to the brain, transcranial drug delivery or small molecules, are discussed, and …Author: William M Pardridge
http://web.stanford.edu/group/pawender/drug-delivery-systems.html
Joel M. Hyman, Erika I. Geihe, Brian M. Trantow, Bahram Parvin, & Paul A. Wender; “A molecular method for the delivery of small molecules and proteins across the cell wall of algae using molecular transporters”, PNAS, 2012, 109 (33), 13225-13230.
https://pharmacy.vcu.edu/pharmaceutics/research/drug-transporters/
Dr. Sweet’s research group uses cell culture, intact tissue, and knockout mouse model systems to: (1) determine the energetics and specificity of the transporters, (2) define the roles of transporters in drug interactions and disease, and (3) identify the mechanisms involved in the modulation of transporter function and expression.
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