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https://www.researchgate.net/publication/231067809_Porous_Hydroxyapatite_Bioceramic_Scaffolds_for_Drug_Delivery_and_Bone_Regeneration
The use of porous hydroxyapatite as a drug delivery system could result in a dual effect: the ability to interact with the bone tissues at the same time ensuring increased drug efficiency ...
https://ui.adsabs.harvard.edu/abs/2011MS&E...18s2019L/abstract
From poly lactic acid and polyvinyl alcohol coated scaffolds gentamicin was released within 20h and 50h, respectively. The conventional methods of supplying a patient with pharmacologic active substances suffer from being very poorly selective, so that damage can occurs to the healthy tissues and organs, different from the intended target.Author: Dagnija Loca, Janis Locs, Kristine Salma, Juris Gulbis, Ilze Salma, Liga Berzina-Cimdina
https://www.researchgate.net/profile/Janis_Locs/publication/231067809_Porous_Hydroxyapatite_Bioceramic_Scaffolds_for_Drug_Delivery_and_Bone_Regeneration/links/02bfe5146bd1a48f1f000000.pdf?inViewer=true&pdfJsDownload=true&disableCoverPage=true&origin=publication_detail
Gentamicin sulphate (Sigma-Aldrich) was used as a model drug for drug delivery system preparation. To prepare local drug delivery system, the porous bioceramic scaffolds were impregnated with. gentamicin water solution. Three impregnation cycles were applied to obtain drug/bioceramic.
http://iopscience.iop.org/article/10.1088/1757-899X/18/19/192019/meta
Porous Hydroxyapatite Bioceramic Scaffolds for Drug Delivery and Bone Regeneration. Dagnija Loca 1, Janis Locs, Kristine Salma, Juris Gulbis, Ilze Salma and Liga Berzina-Cimdina. Published under licence by IOP Publishing Ltd IOP Conference Series: Materials Science and …
https://www.sciencedirect.com/science/article/pii/S1773224719305064
Hydroxyapatite (HAp), as a biomaterial, received extensive attention for biomedical applications in the last 15 years. HAp has been utilized systematically as a filling material for bone defects, artificial bone grafting, and as a scaffold material in prosthesis revision surgery.Author: Sudip Mondal, Umapada Pal
https://www.sciencedirect.com/science/article/pii/B9781782420330000092
Hydroxyapatite (HAp) is a gold standard in the field of synthetic biomaterials used as bone grafts for the purpose of bone regeneration. Upgrading the bone grafts with additional functionality, such as drug delivery, can create the possibility of developing multifunctional implant materials.Author: D. Loca, J. Locs, A. Dubnika, V. Zalite, L. Berzina-Cimdina
https://www.researchgate.net/publication/339134134_Porous_Scaffolds_for_Bone_Regeneration
Effective use of nanocarriers as drug delivery systems for the treatment of ... Please cite this article as: N. Abbasi et al., Porous scaffolds for bone regeneration, ... carbonated hydroxyapatite ...
https://www.sciencedirect.com/science/article/pii/S2468217920300071
Natural variation in bone density occurs in the axial direction of long bones, displaying a gradient in porous structure from cortical bone to cancellous bone . This suggests bone implants made of porous gradient biomaterials that can mimic the properties of natural bone with a porosity-graded structure, may perform significantly better in bone regeneration applications.Author: Naghmeh Abbasi, Stephen Hamlet, Robert M. Love, Nam-Trung Nguyen
https://www.sciencedirect.com/science/article/pii/S0272884220308130
A review of bioceramic porous scaffolds for hard tissue applications: Effects of structural features ... polymeric carriers can be used, for example, for the effective delivery of a drug, metabolic supplement, or a growth factor to the body. ... (BCP), which are a combination of β-TCP and HAp, serve as scaffolds with superior bone regeneration ...
https://www.sciencedirect.com/science/article/pii/S0272884211006481
The particle size distribution of the crushed hydroxyapatite powder and as synthesized porous scaffold are shown in Fig. 5. The hydroxyapatite powder presents a mono-modal distribution with an average particle size of 6.5 μm, whereas the crushed hydroxyapatite scaffolds present a blunt bimodal distribution with two maxima at ∼6.5 and ∼61 μm.Author: Garima Tripathi, Bikramjit Basu
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