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https://www.sigmaaldrich.com/technical-documents/articles/material-matters/polymersomes-for-drug-delivery.html
Due to these benefits, polymersomes have been extensively explored in various biomedical applications such as drug delivery, 3,4 gene and protein delivery, 5 imaging, 6 and diagnostics. 7 This article will focus specifically on polymersomes for drug delivery.
https://www.sciencedirect.com/science/article/pii/S0168365911009576
The acidic environment of cancerous tissues (pH 6.5–7.2) , , endosomes (pH 5.0–6.5) and lysosomes (pH 4.5–5.0) has been utilized for anticancer drug delivery and intracellular drug delivery. A general strategy for targeted drug delivery is based on carriers, in which drugs remain encapsulated during circulation in blood at physiological ...Author: Jung Seok Lee, Jan Feijen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470373/
Polymersomes are stable vesicles prepared from amphiphilic polymers and are more stable compared with liposomes. Although these nanovesicles have many attractive properties for in vitro/in vivo applications, liposome-based drug delivery systems are still prevalent in the market. In order to expedite the translational potential and to provide medically valuable formulations, the polymersomes ...Author: Tayebeh Anajafi, Sanku Mallik
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630455/
May 30, 2019 · The obtained polymersomes, containing gold nanorods and doxorubicin, were tested for their potential use as nanometric photothermal agents and drug delivery systems. The polymersomes are able to release their content as a response to changes in the pH of the environment, and also in response to temperature changes induced by the absorption of ...Author: Melissa DiazDuarte-Rodriguez, Norma A. Cortez-Lemus, Angel Licea-Claverie, Jacob Licea-Rodriguez, Eu...
http://pubs.acs.org/doi/abs/10.1021/bm801127d
In the past decade, polymersomes (also referred to as polymeric vesicles) have attracted rapidly growing interest based on their intriguing aggregation phenomena, cell and virus-mimicking dimensions and functions, as well as tremendous potential applications in medicine, pharmacy, and biotechnology. Unlike liposomes self-assembled from low molecular weight lipids, polymersomes are in general ...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/polymersome
This chemoresistance arises over time through drug inactivation, drug target alteration, drug efflux, DNA damage repair, or cell death inhibition. Interesting work done by Xu et al. describes the development of polymersomes as a drug delivery agent and could be potentially effective in …
https://www.researchgate.net/publication/320004497_Polymersomes_in_Drug_Delivery_A_Comparative_Review_with_Liposomes_and_Micelles
Since the mid 50's, enormous attention has been paid towards nanocarriers and their applications in drug and gene delivery. Among these vesicles, liposomes and micelles have been heavily ...
https://pubs.acs.org/doi/abs/10.1021/acs.biomac.6b00350
We used three-dimensional spheroid cultures of pancreatic cancer cells BxPC-3 to demonstrate hypoxia-mediated release of the drugs from the polymersomes. The vesicles were nontoxic. However, a significant decrease in cell viability was observed in hypoxic spheroidal cultures of BxPC-3 cells in the presence of drug encapsulated polymersomes.Author: Prajakta Kulkarni, Manas K. Haldar, Seungyong You, Yongki Choi, Sanku Mallik
https://iopscience.iop.org/article/10.1088/1361-6528/ab6bf1
Polymeric nanoparticles, namely polymersomes, have gained traction as a potential solution to drug targeting and delivery due to their ability to encapsulate both hydrophilic and hydrophobic molecules, offer immune shielding, and exhibit low toxicity.Author: Nicholas L’Amoreaux, Aon Ali, Shoaib Iqbal, Jessica Larsen
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