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https://www.sciencedirect.com/science/article/pii/S0168365908006834
Mar 04, 2009 · Small interfering RNAs (siRNA) are typically ~ 23 bp in length and utilize a cell's own RNA interference pathways to catalyze the degradation of targeted mRNA transcripts , whereas antisense oligonucleotides (AON) are single-stranded and can act additionally by altering splicing of pre-mRNA . While many diseases might be approached by direct knockdown, at least one disease that now …Author: Younghoon Kim, Manorama Tewari, J. David Pajerowski, Shenshen Cai, Shamik Sen, Jason Williams, Shash...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740336/
Mar 04, 2009 · Delivery can be a problem even though antisense oligos are far smaller than plasmids. Small interfering RNAs (siRNA) are typically ∼23 bp in length and utilize a cell's own RNA interference pathways to catalyze the degradation of targeted mRNA transcripts [ 3 ], whereas antisense oligonucleotides (AON) are single-stranded and can act additionally by altering splicing of pre-mRNA …Author: Younghoon Kim, Manorama Tewari, J. David Pajerowski, Shenshen Cai, Shamik Sen, Jason Williams, Shash...
https://europepmc.org/articles/PMC2740336
Nov 12, 2008 · siRNA and antisense oligonucleotides, AON, have similar size and negative charge and are often packaged for in vitro delivery with cationic lipids or polymers-but exposed positive charge is problematic in vivo. Here we demonstrate loading and functional delivery of RNAi and AON with non-ionic, nano-transforming polymersomes.Author: Younghoon Kim, Manorama Tewari, J. David Pajerowski, Shenshen Cai, Shamik Sen, Jason Williams, Shash...
https://www.aiche.org/conferences/aiche-annual-meeting/2008/proceeding/paper/478c-polymersome-delivery-sirna-and-antisense-oligonucleotides
Nov 19, 2008 · Here we demonstrate loading and functional delivery of RNAi and AON with neutral, nano-transforming polymersomes. These degradable carriers are taken up passively by cultured cells after which the vesicles transform into micelles that allow endolysosomal escape and delivery of either siRNA into cytosol for mRNA knockdown or else AON into the nucleus for exon skipping within pre-mRNA.
https://www.researchgate.net/publication/267354667_Polymersome_Delivery_of_siRNA_and_Antisense_Oligonucleotides
siRNA and antisense oligonucleotides, AON, have similar size and negative charge and are often packaged for in vitro delivery with cationic lipids or polymers but positively charged assemblies are...
https://www.researchgate.net/publication/23664843_Polymersome_delivery_of_siRNA_and_antisense_oligonucleotides
siRNA and antisense oligonucleotides, AON, have similar size and negative charge and are often packaged for in vitro delivery with cationic lipids or polymers-but exposed positive charge is...
https://www.academia.edu/7664024/Polymersome_delivery_of_siRNA_and_antisense_oligonucleotides
Polymersome delivery of siRNA and antisense oligonucleotides
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201914751
Jan 29, 2020 · Abstract Current antisense oligonucleotide (ASO) therapies for the treatment of central nervous system (CNS) disorders are performed through invasive administration, thereby placing a …Author: Hyun Su Min, Hyun Jin Kim, Mitsuru Naito, Satomi Ogura, Kazuko Toh, Kotaro Hayashi, Beob Soo Kim, Sh...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743652/
Within the RISC, the siRNA is unwound, the sense strand is discarded, and the antisense or guide strand binds mRNA. When siRNA is fully complementary to its target, an endonuclease, AGO2, a component of RISC, cleaves the mRNA 10 and 11 nucleotides downstream from the 5′-end of the antisense strand. (6) (Fig.Author: Ryszard Kole, Adrian R. Krainer, Sidney Altman
https://en.wikipedia.org/wiki/Antisense_therapy
Antisense therapy is a form of treatment for genetic disorders or infections. When the genetic sequence of a particular gene is known to cause a particular disease, it is possible to synthesize a strand of nucleic acid (DNA, RNA or a chemical analogue) that will bind to the messenger RNA (mRNA) produced by that gene and inactivate it, effectively turning that gene "off".
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