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https://www.ncbi.nlm.nih.gov/pubmed/21727469
Polymeric worm micelles as nano-carriers for drug delivery. Kim Y(1), Dalhaimer P, Christian DA, Discher DE. Author information: (1)Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. Nanoscale carriers of active compounds, especially drugs, need not be spherical in shape.Author: Younghoon Kim, Paul Dalhaimer, David A Christian, Dennis E Discher
https://iopscience.iop.org/article/10.1088/0957-4484/16/7/024
May 18, 2005 · Spherical micelles formed from various amphiphilic copolymers are being used as nanoscale drug delivery vehicles to (1) increase the solubility of hydrophobic drugs, (2) reduce toxicity to healthy tissue caused from excess dosage, and (3) achieve more sustained release profiles of drugs …Author: Younghoon Kim, Paul Dalhaimer, David A Christian, Dennis E Discher
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113619/
Apr 04, 2014 · Polymeric micelles represent an effective delivery system for poorly water-soluble anticancer drugs. With small size (10–100 nm) and hydrophilic shell of PEG, polymeric micelles exhibit prolonged circulation time in the blood and enhanced tumor accumulation.Author: Yifei Zhang, Yixian Huang, Song Li
https://www.researchgate.net/publication/51465660_Polymeric_worm_micelles_as_nano-carriers_for_drug_delivery
Nanoscale carriers of active compounds, especially drugs, need not be spherical in shape. Worm micelles as blends of degradable polylactic acid (PLA) and inert block copolymer amphiphiles were prepared for controlled release and initial study of carrier transport through nano-porous media.
http://adsabs.harvard.edu/abs/2005Nanot..16S.484K
Perhaps equally important for application is the flexibility of worm micelles, which we show allows them to penetrate nanoporous gels where 100 nm sized vesicles cannot enter. Such gels have served as tissue models, and so the results here collectively suggest a new class of hydrophobic drug nano-carriers that are capable of tissue permeation ...
https://pubs.acs.org/doi/10.1021/mp400639e
Jul 24, 2014 · Overall, the results indicate that MPEG-dihexPLA micelles are highly efficient nanocarriers for the selective cutaneous delivery of tacrolimus, superior to the marketed formulation (Protopic). Furthermore, they may also have significant potential for targeted delivery to the hair follicle.Author: Maria Lapteva, Karine Mondon, Michael Möller, Robert Gurny, Yogeshvar N. Kalia
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