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https://www.ncbi.nlm.nih.gov/pubmed/21858246
Polymeric vectors for ocular gene delivery. Tamboli V(1), Mishra GP, Mitrat AK. Author information: (1)Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, MO 64108-2718, USA. Gene therapy holds promise for the treatment of many inherited and acquired diseases of the eye.Author: Viral Tamboli, Gyan P Mishra, Ashim K Mitra
https://www.future-science.com/doi/abs/10.4155/tde.11.20
Among nonviral delivery systems, polymeric vectors have gained significant attention in recent years owing to their nontoxic and non-immunogenic nature. Polyplexes or nanoparticles can be prepared by interaction of cationic polymers with DNA, which facilitate cellular uptake, endolysosomal escape and nuclear entry through active mechanisms.Author: Viral Tamboli, Gyan P Mishra, Ashim K Mitra
https://www.researchgate.net/publication/51587054_Polymeric_vectors_for_ocular_gene_delivery
Successful ocular gene therapy interventions depend on efficient gene transfer to targeted cells with minimal toxicity. A major challenge is to overcome both intracellular and extracellular ...
http://europepmc.org/articles/PMC3156448
Polymeric vectors in ocular gene delivery. Synthetic and natural polymer-mediated gene delivery has gained attention in recent years. Large-scale production and chemical modification of polymeric vectors is feasible. Polymeric vectors are very effective where low therapeutic levels of nucleic acids are required over a short duration.
https://www.sciencedirect.com/science/article/abs/pii/S0928493117309827
Aug 01, 2017 · Development of non-viral vectors for ocular gene therapy shows great promise. Current strategies privilege polymer-based vectors for retinal gene delivery using natural polymers Most common optimizations of polymer-based vectors include chemical modifications.Author: Ana V. Oliveira, Ana M. Rosa da Costa, Gabriela A. Silva
https://pubs.acs.org/doi/10.1021/bc990025r
Cationic polymer/DNA complexes are widely used for gene delivery, although the influence of the cationic polymer on the biophysical properties of the resulting complex is poorly understood. Here, several series of cationic polymers have been used to evaluate the influence of structural parameters on properties of DNA complexes.Author: Margreet A. Wolfert, Philip R. Dash, Ola Nazarova, David Oupicky, Leonard W. Seymour, Sarah Smart, J...
https://www.sciencedirect.com/science/article/pii/S016777991830060X
Gene delivery mediated by polymeric vectors is a multistage process. It involves multiple obstacles to overcome before the nucleic acid material can reach the target site (Figure 1, Key Figure). The target site here refers to the cytosol for RNA molecules and the nucleus for plasmids.Author: Wing-Fu Lai, Wing-Fu Lai, Wing-Tak Wong
https://www.mdpi.com/journal/polymers/special_issues/polymers_in_gene_delivery
Gene therapy has been at the forefront of drug delivery research for the past three decades. To overcome the barriers of gene delivery, different types of non-viral delivery systems, including polymers, have been developed and advanced to clinical …
https://www.mdpi.com/1999-4923/12/4/335/htm
As an alternative to eye drops and ocular injections for gene therapy, the aim of this work was to design for the first time hydrogel contact lenses that can act as platforms for the controlled delivery of viral vectors (recombinant adeno-associated virus, rAAV) to the eye in …
https://www.ncbi.nlm.nih.gov/pubmed/26349389/
Polymeric Nanocarriers for Non-Viral Gene Delivery. Li L, Wei Y, Gong C. Gene therapy holds great promise for the treatment of acquired and inherited diseases. Non-viral gene delivery systems are gaining recognition as alternatives to viral gene vectors due to their safety and low immunogenicity.Author: Ling Li, Yuquan Wei, Changyang Gong
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