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http://www.biopharminternational.com/oral-delivery-and-recombinant-production-peptide-hormones
Jun 01, 2004 · The low bioavailability associated with oral delivery necessitates a large-scale, cost-effective production technology. Part II of this article will be published in an upcoming issue and will describe a direct-expression, recombinant peptide-production technology that is readily scalable to economically produce hundreds of kg/yr.
http://www.biopharminternational.com/oral-delivery-and-recombinant-production-peptide-hormones-part-ii-recombinant-production-therapeutic
This technology includes an efficient and scalable in vitro enzymatic amidation step for peptide hormones. Oral Delivery and Recombinant Production of Peptide Hormones, Part II: Recombinant Production of Therapeutic Peptides BioPharm International
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815093/
Jan 25, 2010 · To extend and further validate the application of Tf-based recombinant fusion protein approach for oral delivery, we investigated the feasibility of producing bioactive human growth hormone-transferrin fusion protein in mammalian embryonic kidney cells (HEK293T), focusing on oral absorption.Author: Nurmamet Amet, Wei Wang, Wei-Chiang Shen
https://www.genscript.com/recombinant_pep.html
Low Cost: Our recombinant peptide package provides a cost-effective approach for large-scale, long, and complicated peptide production. In addition, recombinant peptides may be regenerated, further decreasing long-run expenses. Batch-to-Batch Consistency: With fewer steps than conventional peptide synthesis, recombinant peptide technology ...
https://www.sciencedirect.com/science/article/pii/S1319016414000590
A review on the strategies for oral delivery of proteins and peptides and their clinical perspectives. ... recombinant DNA, protein and peptide engineering and tissue culture techniques can now be used to obtain proteins and peptides for therapeutic use on a commercial scale which resemble an endogenous molecule and thus provoke fewer or ...Author: Abdul Muheem, Faiyaz Shakeel, Mohammad Asadullah Jahangir, Mohammed Anwar, Neha Mallick, Gaurav Kuma...
https://www.ncbi.nlm.nih.gov/pubmed/26787260
INTRODUCTION: Oral delivery of therapeutic peptide hormones offers the promise of greater patient compliance when compared to parenteral administration routes. However, it is a huge challenge in the pharmaceutical field. Due to increasing demand for oral delivery of peptide hormones such as insulin, gonadotropin-releasing hormones, and ...Author: Pegah Varamini, Istvan Toth
https://en.wikipedia.org/wiki/Recombinant_peptide_production
Protein production is the biotechnological process of generating a specific protein.It is typically achieved by the manipulation of gene expression in an organism such that it expresses large amounts of a recombinant gene.This includes the transcription of the recombinant DNA to messenger RNA (), the translation of mRNA into polypeptide chains, which are ultimately folded into functional ...
https://www.sciencedirect.com/science/article/pii/S0378517312003249
However it is not feasible for direct delivery of peptide and protein drugs. To overcome the gastro-intestinal barriers various types of formulations such as polymeric micro/nanoparticles, liposomes, etc. are investigated. In the recent years lot of advances have taken place in developing and understanding the oral peptide delivery systems.Author: M.R. Rekha, Chandra P. Sharma
https://www.researchgate.net/publication/307969048_Oral_Delivery_of_Pentameric_Glucagon-Like_Peptide-1_by_Recombinant_Lactobacillus_in_Diabetic_Rats
Oral Delivery of Pentameric Glucagon-Like Peptide-1 by Recombinant Lactobacillus in Diabetic Rats Article (PDF Available) in PLoS ONE 11(9):e0162733 · September 2016 with 129 Reads
http://www.biology.50webs.com/rhormone.htm
RECOMBINANT HORMONE PRODUCTION. In the human body, peptide hormones are secreted after encoding by peptide hormone genes in the specialized cells, for instance insulin and other Human Growth Hormone (hGH). INSULIN. This peptide hormone is secreted by the b cells of Islets of Langerhans of pancreas which catabolises glucose in blood. Insulin is ...
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