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https://onlinelibrary.wiley.com/doi/10.1002/9780470688397.ch13
Summary This chapter contains sections titled: Introduction Microparticles Based on Poly(Lactic‐co‐Glycolic Acids) (PLGA) Other Types of Polymer Microparticles Conclusions References Polymer Microparticles for Nucleic Acid Delivery - Delivery Technologies for Biopharmaceuticals - Wiley Online LibraryAuthor: Timothy R Pearce, Jared Hierman, Chun Wang
https://experts.umn.edu/en/publications/polymer-microparticles-for-nucleic-acid-delivery
PLGA microparticle performance for nucleic acid delivery PLGA- random copolymer of lactic acid and glycolic acid Polycation incorporation into PLGA microparticle formulationAuthor: Timothy R Pearce, Jared Hierman, Chun Wang
https://patents.google.com/patent/US5783567A/en
Disclosed is a preparation of microparticles made up of a polymeric matrix and a nucleic acid expression vector. The polymeric matrix includes one or more synthetic polymers having a solubility in water of less than about 1 mg/l. At least 90% of the microparticles have a …Author: Mary Lynne Hedley, Joanne M. Curley, Robert S. Langer
https://academic.oup.com/nar/article/37/22/e145/2409841
Sep 25, 2009 · In contrast to delivery vehicles composed of cationic lipids or polycations, the PKCNs are ‘hard’ materials composed of water-insoluble polymers and have a strong thermodynamic driving force to maintain their integrity in vivo. The PKCNs are acid sensitive, and hydrolyze after phagocytosis in the acidic environment of the phagosome, allowing them to rapidly release siRNA after cell internalization …Author: Sungmun Lee, Stephen C. Yang, Chen-Yu Kao, Robert H. Pierce, Niren Murthy
https://patents.google.com/patent/EP1005374A1/en
EP1005374A1 - Microparticles for delivery of nucleic acid - Google Patents Disclosed is a preparation of microparticles made up of a polymeric matrix and a nucleic acid expression …Author: Mary Lynne Hedley, Joanne M. Curley, Robert S. Langer
https://pubs.acs.org/doi/full/10.1021/ar200232n
In this Account, we highlight examples of polycation–PAO conjugates, liposome–PAO formulations, and PAO micelles for nucleic acid delivery. Among the various polymer design considerations, which include molecular weight of polymer, molecular weight of blocks, and length of blocks, the overall hydrophobic–lipophilic balance (HLB) is a ...Author: Swati Mishra, Lavanya Y Peddada, David I Devore, Charles M Roth
https://www.sigmaaldrich.com/technical-documents/articles/material-matters/delivery-of-nucleic-acids-using-polymers.html
In contrast to highly efficient viral delivery vectors, non-viral counterparts bear less immunostimulatory, mutagenetic, and oncogenic complications; some can approach transfection efficiencies comparable to viruses. 17 Therapeutic nucleic acids of interest for nanomedicine can be DNA in plasmids (pDNA), antisense oligonucleotides (AONs), ribozymes, DNAzymes, and more recently, siRNA and shRNA. …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185908/
Feb 01, 2014 · PEI is a cationic polymer widely used for nucleic acid delivery. 21 It is particularly promising vector with relatively high level of transfection in a number of target organs. The high charge density of PEI is thought to be a key factor that contributes to its high transfection efficiency.Author: Azam Bolhassani, Shabnam Javanzad, Tayebeh Saleh, Mehrdad Hashemi, Mohammad Reza Aghasadeghi, Seyed ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893903/
Polymers can also be used to encapsulate nucleic acids for in vivo delivery. Generally, polymers can be divided into two groups: natural or synthetic. Biologically occurring molecules such as peptides, oligosaccharides, and even nucleic acids themselves are natural polymers.Author: Emily B. Harrison, Salma H. Azam, Chad V. Pecot
https://www.sciencedirect.com/science/article/pii/S0168365915301462
Intracellular nucleic acid delivery has the potential to treat many genetically-based diseases, however, gene delivery safety and efficacy remains a challenging obstacle. One promising approach is the use of polymers to form polymeric nanoparticles with nucleic acids that have led to exciting advances in non-viral gene delivery.Author: Corey J. Bishop, Kristen L. Kozielski, Jordan J. Green, Jordan J. Green
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