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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178968/
Chitosan is a nontoxic, biodegradable, biocompatible and bioactive polymer. Chitosan is used as excipient and drug carrier in drug delivery systems. Chitosan is used for the colon targeted drug delivery because it has a tendency to dissolve in acidic pH of stomach but get swollen in the intestinal pH.
http://pharmaquest.weebly.com/uploads/9/9/4/2/9942916/polymers_for_colon_dds.pdf
Rajpurohit, et al.: Polymers for Colon Targeted Drug Delivery The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration.
https://www.sciencedirect.com/science/article/pii/0168365992900708
The enzy- by microbial enzymes in the colon for the deliv- matic activity of colonie microflora can be used ery of peptides (proteins). 122 Bioadhesive water soluble polymers for colon-specific drug delivery Microbial azoreductases are predominantly present in the colon of different species and they are able to cleave aromatic azobonds on water soluble polymers [ 1 ].Author: J. Kopeček, P. Kopečková, H. Brøndsted, R. Rathi, B. R̆íhová, P.-Y. Yeh, K. Ikesue
https://www.researchgate.net/publication/51691398_Polymers_for_Colon_Targeted_Drug_Delivery
The pharmaceutical strategies that are commonly used to achieve a colon-specific drug delivery system include time, pH-dependent polymer coating, prodrug, colonic microbiota-activated delivery ...
https://www.sciencedirect.com/science/article/pii/S002235491550453X
Van den Mooter, C. Samyn, R. Kinget, Azo polymers for colon-specific drug delivery. II: Influence of the type of azo polymer on the degradation by intestinal microflora Int. J. Pharm. 97: (1993) 133-139 19.Author: G. Van Den Mooter, B. Maris, C. Samyn, P. Augustijns, R. Kinget
https://www.elsevier.com/books/applications-of-polymers-in-drug-delivery/misra/978-0-12-819659-5
Oct 01, 2020 · Polymers play a crucial role in modulating drug delivery and have been fundamental in the successful development of many novel drug delivery systems. This book describes the development of polymeric systems, ranging from conventional dosage forms to …Book Edition: 2
https://www.japsonline.com/admin/php/uploads/761_pdf.pdf
potential as colon specific drug carrier systems are chitosan, pectin, chondroitin sulphate, cyclodextrin, dextrans, guar gum, insulin, amylase and bean gum. Approaches being used for new anticonvulsant drugs include the search for agents that block specific cationic channels in neuronal membranes, agents that
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215502/
Feb 07, 2010 · The polymers described as pH dependent in colon specific drug delivery are insoluble at low pH levels but become increasingly soluble as pH rises. 21 Although a pH dependent polymer can protect a formulation in the stomach, and proximal small intestine,...Author: Anil K. Philip, Betty Philip
http://ijpsr.com/bft-article/a-review-on-colon-targeted-drug-delivery-system/?view=fulltext
A REVIEW ON COLON TARGETED DRUG DELIVERY SYSTEM HTML Full Text. A REVIEW ON COLON TARGETED DRUG DELIVERY SYSTEM. Anita * 1, Anil Singh 1 and Ankit Dabral 2. Himalayan Garhwal University 1, Dhaid Gaon, Shiv Nagar, Block Pokhara, Pauri Garhwal - 246169, Uttarakhand, India.. Shri Guru Ram Rai Institute of Technology and Science 2, Dehradun - 248121, Uttarakhand, …
https://www.slideshare.net/GajananSanap/colon-targeted-drug-delivery-systems
Feb 27, 2016 · Azo polymeric new drug In which use of polymers as drug carriers for drug delivery to colon . Synthetic, naturally, sub-synthetic polymers used form colon targeted polymeric prodrug with azo linkage between polymer & drug moiety. The various azo polymers are evaluated for coating materials over drug core.
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