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https://advances.sciencemag.org/content/6/5/eaax4690.full
Jan 01, 2020 · Intratumoral delivery of CCL25 or CD47 siRNA alone failed to induce significant antitumor responses, suggesting that both the number of CCR9 + TILs and the tumor microenvironment are crucial in antitumor immunity. Treatment with NP-siCD47/CCL25, but not monotherapy with NP-siNC/CCL25, ...Author: Hongmei Chen, Xiuxiu Cong, Chenxi Wu, Xuan Wu, Jialiang Wang, Jialiang Wang, Kuirong Mao, Kuirong Ma...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787988/
Dec 16, 2009 · Surface-Engineered Targeted PPI Dendrimer for Efficient Intracellular and Intratumoral siRNA Delivery Oleh Taratula , a, b Olga B. Garbuzenko , a Paul Kirkpatrick , b Ipsit Pandya , b Ronak Savla , a, b Vitaly P. Pozharov , a Huixin He , b, * and Tamara Minko a, *Author: Oleh Taratula, Olga B. Garbuzenko, Paul Kirkpatrick, Ipsit Pandya, Ronak Savla, Vitaly P. Pozharov, ...
https://www.ncbi.nlm.nih.gov/pubmed/26840082
Feb 23, 2016 · Antibody targeting facilitates effective intratumoral siRNA nanoparticle delivery to HER2-overexpressing cancer cells. ... Department of Bioengineering and Center for Intracellular Delivery of Biologics, University of Washington, Seattle, WA, USA. ... Delivery of siRNA via antibody-directed endosomolytic nanoparticles may be a promising ...Author: Maria C. Palanca-Wessels, Garrett C. Booth, Anthony J. Convertine, Brittany B. Lundy, Geoffrey Y. Be...
https://www.sciencedirect.com/science/article/pii/S0168365909004404
Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery. ... The siRNA complexes were prepared at an amine/phosphate (N/P) ... digested in 2 h. These results are in a good corroboration with the data obtained by Kim et al. for the PEGylated siRNA delivery system based on polyethylenimine ...Author: Oleh Taratula, Olga B. Garbuzenko, Paul Kirkpatrick, Ipsit Pandya, Ronak Savla, Vitaly P. Pozharov, ...
https://www.researchgate.net/publication/292978712_Antibody_targeting_facilitates_effective_intratumoral_siRNA_nanoparticle_delivery_to_HER2-overexpressing_cancer_cells
Antibody targeting facilitates effective intratumoral siRNA nanoparticle delivery to HER2-overexpressing cancer cells Maria C. Palanca-Wessels 1,2,* , Garrett C. Booth 1 , Anthony J. Convertine 3 ...
https://www.liebertpub.com/doi/10.1089/nat.2018.0726
Jun 01, 2018 · This class of nanoparticles has been shown to deliver nucleic acids to cells in an ApoE independent manner unlike MC3 and related lipid systems. The application of C12-200 to mRNA delivery was conducted starting with the composition that was originally developed for siRNA delivery [42]. Using design of experiment (DoE) principles, the ...Author: Matthew G. Stanton
http://www.nature.com/articles/nbt1101
May 22, 2005 · Delivery of small interfering RNAs (siRNAs) into cells is a key obstacle to their therapeutic application. We designed a protamine-antibody fusion protein to deliver siRNA to HIV-infected or ...Author: Erwei Song, Pengcheng Zhu, Sang Kyung Lee, Dipanjan Chowdhury, Steven Kussman, Derek M Dykxhoorn, Yi...
https://www.sciencedirect.com/science/article/abs/pii/S0168365909004404
Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery. Author links open overlay panel Oleh Taratula a b Olga B. Garbuzenko a Paul Kirkpatrick b Ipsit Pandya b Ronak Savla a b Vitaly P. Pozharov a Huixin He ...Author: Oleh Taratula, Olga B. Garbuzenko, Paul Kirkpatrick, Ipsit Pandya, Ronak Savla, Vitaly P. Pozharov, ...
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