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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131473/
However, their impacts on nanoparticle-based drug delivery have begun to receive due attention only recently. This article reviews biological features of many solid tumors that influence transport of drugs and nanoparticles and properties of nanoparticles relevant to their intratumoral transport, studied in …Author: Hillary Holback, Yoon Yeo
https://www.sciencedirect.com/science/article/pii/S0168365915302388
For intratumoral drug delivery, the ideal requirement would be an aqueous polymer solution that easily flows at room temperature followed by formation of gel at physiological temperature (37 °C) . For this approach, both synthetic and natural polymeric materials are considered , , , , .Author: Amir Fakhari, J. Anand Subramony
https://drug-dev.com/intratumoral-delivery-combining-local-systemic-treatments-could-immuno-oncology-finally-enable-local-intratumoral-delivery/
The second approach is to be more precise by administering the drug directly into the tumors, ie, intratumoral delivery. Both regional and intratumoral delivery spare the majority of the body of the ill effects of chemotherapeutic agents. The Challenges of Intratumoral Delivery There are many cancers that originate deep in the body.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1715923/
Effect of Intratumoral Injection on the Biodistribution and the Therapeutic Potential of HPMA Copolymer-Based Drug Delivery Systems 1, 2. ... Intratumoral injection, drug delivery systems, polymer ... drug delivery systems designed specifically for topical administration can be expected to be more suitable for i.t. administration than are ...Author: Twan Lammers, Twan Lammers, Peter Peschke, Rainer Kühnlein, Vladimir Subr, Karel Ulbrich, Peter Hube...
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.201801309
This phenomena, known as the PEG dilemma, is a well‐recognized challenge in drug delivery. 38, 39 We expect that our bacteria‐based therapeutic agents can uniquely overcome this dilemma, as the PEG coating will facilitate enhanced initial uptake and intratumoral transport, but over time, bacterial proliferation leads to erosion of the PEG ...Author: SeungBeum Suh, Ami Jo, Mahama A. Traore, Ying Zhan, Sheryl L. Coutermarsh‐Ott, Veronica M. Ringel‐Sc...
https://drug-dev.com/intratumoral-delivery-arming-the-immune-system-turning-cold-tumors-hot/
In preclinical and clinical studies, intratumoral delivery of DNA-based interleukin-12 (IL-12–tavokinogene telseplasmid; tavo) by way of intratumoral, avoids the toxicity of systemic immune stimulation
https://pdfs.semanticscholar.org/4e9e/aa449a1996b9bf4d676c392de98adb1ad318.pdf
airway lumen, intratumoral delivery of cytotoxic drugs may be regarded as an improved neoadjuvant therapy for use prior to irradiation and/or surgery. EITC differs significantly from conventional intravenous chemotherapy by virtue of the localized non-systemic route of drug delivery. The advantages include: precise delivery of a drug
https://jtultrasound.biomedcentral.com/articles/10.1186/2050-5736-3-S1-P48
Jun 30, 2015 · An approach of drug delivery to hypovascular tumor tissues is proposed. For such tumor tissues, it is difficult to deliver anti-tumor agents at enough concentration and duration by either systemic or local administration.Author: Ken-ichi Kawabata, Maruoka Takashi, Rei Asami, Reiko Ashida
https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.8_suppl.38
38 Background: There has been a renaissance in the concept of promoting the immune-responsiveness of the tumor immune microenvironment via intratumoral (IT) delivery of immunostimulatory agents. As with any invasive intervention, though, outcomes following intratumoral drug delivery depend on procedural technique. We have previously shown that multi-sidehole needles (MSHNs) provide a 3 …Author: Rahul Sheth, Nina Munoz, Crystal Dupuis, Malea Williams, Katherine Dixon, Kiersten Maldonado, Ravi M...
https://clincancerres.aacrjournals.org/content/11/2/826
Jan 15, 2005 · Purpose: Paclitaxel is a highly promising phase-sensitive antitumor drug that could conceivably be improved by extended lower dosing as opposed to intermittent higher dosing. Although intratumoral delivery of paclitaxel to the whole tumor at different loads and rates has already been achieved, determining an optimal release mode of paclitaxel for tumor eradication remains difficult. …Author: Abraham Rami Tzafriri, Elyakum Itzhak Lerner, Moshe Flashner-Barak, Michael Hinchcliffe, Eli Ratner,...
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