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https://www.researchgate.net/publication/221745681_Polypeptides_and_polyaminoacids_in_drug_delivery
Polypeptides and polyaminoacids in drug delivery Article · Literature Review in Expert Opinion on Drug Delivery 9(2):183-201 · February 2012 with 66 Reads How we measure 'reads'
https://www.pharmaexcipients.com/excipient-suppliers-list/pmc-isochem/
Polyamino acid based biopolymers for nanoencapsulation, polymer drug conjugates and formulation of proteins Activated amino acids for polyamino acids synthesis and use in drug delivery CDMO services: APIs and news chemical entities, development, clinical supply, commercial GMP manufacturing
https://www.ncbi.nlm.nih.gov/pubmed/29978708
Jul 25, 2018 · 1. ACS Appl Mater Interfaces. 2018 Jul 25;10(29):24392-24405. doi: 10.1021/acsami.8b06642. Epub 2018 Jul 16. Polyamino Acid Layer-by-Layer (LbL) Constructed Silica-Supported Mesoporous Titania Nanocarriers for Stimuli-Responsive Delivery of microRNA 708 and Paclitaxel for Combined Chemotherapy.
https://www.sciencedirect.com/topics/chemistry/polyaminoacid
The hydrolytic instability of the amide bond in synthetic amino acid polymers has also been used in the formation of intentionally degradable soluble polymers for drug delivery, as described by Duncan and Kopacek. 33,44 These polymers are designed to give controlled biodegradation via the introduction of segments susceptible to effects by ...
https://www.researchgate.net/publication/303404448_Polyaminoacid_nanocapsules_for_drug_delivery_to_the_lymphatic_system_Effect_of_the_particle_size
Request PDF Polyaminoacid nanocapsules for drug delivery to the lymphatic system: Effect of the particle size Previous work by our group showed the possibility to reduce the toxicity of ...
https://www.alamanda-polymers.com/node
Poly-D,L-glutamic acid sodium salt is a negatively charged synthetic polyamino acid having one Na per glutamic acid unit. It is a crystalline solid soluble in water. Applications for poly-D,L-glutamic acid sodium salt include the conjugation to active molecules for improved activities and the layer-by-layer deposition techniques for surface ...
https://patents.google.com/patent/US6576254B1/en
There is provided polymeric vesicles formed from polyamino acid derivatives for use in the delivery of therapeutic agents. The polyamino acid is modified so as to bear at least one hydrophilic group and at least one hydrophobic group. Vesicle formation is then induced in the presence of cholesterol. The vesicles are suited for entrapment or conjugation of pharmaceutically active agents, in ...
https://pubs.acs.org/doi/10.1021/acsami.8b06642
Polyamino Acid Layer-by-Layer (LbL) Constructed Silica-Supported Mesoporous Titania Nanocarriers for Stimuli-Responsive Delivery of microRNA 708 and Paclitaxel for Combined Chemotherapy. ... New Advances in In Vivo Applications of Gated Mesoporous Silica as Drug Delivery Nanocarriers.
https://pmcisochem.fr/page/polyamino-acids
Which delivery technology? A biomaterial toolbox for various Nanotechnologies and Drug Conjugates What polymeric structure? What is the value of our services? PMC Isochem: a CDMO for GMP polyamino acids integrated in strategic monomers (NCAs) Standard and customized polyamino acids and functionalization; Development and characterization
https://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.7b00444
A natural polysaccharide-based nanogel has been synthesized and characterized as pH-sensitive drug delivery system for poorly water-soluble anticancer drugs. In this work, methacrylated hyaluronic acid (MAHA) was used to prepared acid degradable nanogels by a surfactant-free polymerization method in water, where 2,2-dimethacroyloxy-1-ethoxypropane (DMAEP) served as a pH labile cross-linker ...
https://www.pharmacompass.com/pharma-services/drug-product-fdf-manufacturing-services/technologies/drug-delivery
- Service Details. PMC Isochem offers custom development & manufacturing of Vitamin E TPGS (Tocophersolan) and amino acid based polymers for drug delivery solutions.They have expertise in polyamino acid based drug delivery technology.
https://patents.google.com/patent/EP2664340A3/en
A61K47/642 — Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the ...
https://www.nanosoftpolymers.com/product/n3-pll/
Azide capped poly(L-lysine) (N3-PLL) is a functional cationic polyamino acid used for surface modification or gene/drug delivery. The azide-PLL can be modified by alkyne-containing moieties through click chemistry.
https://link.springer.com/article/10.1023/A:1016053128569
Purpose. A biodegradable carrier for the liver-specific delivery of drugs was developed using poly-L-glutamic acid (PLGA) modified with galactose (galactosylated PLGA or Gal-PLGA), and its feasibility was investigated in mice. Methods. 111In-PLGA and 111In-Gal-PLGAs were injected in mice and their distribution and biodegradation properties were studied. Results. After intravenous injection ...
https://pmcisochem.fr/sites/default/files/Chemistry%20Today%20-%2033(4)%20July%20August%202015%20HR.pdf
KEYWORDS: α-amino acid N-Carboxy Anhydrides, NCA, Urethane α-Amino acid N-Carboxy Anhydrides, UNCA, Ring Opening Polymerization, ROP, Peptide, Polypeptide, Polyamino acid, Amino acid coupling, Drug delivery, Active pharmaceutical ingredient. Abstract α-Amino acid Ν-Carboxy Anhydrides (NCA) have been discovered over a century ago (1). The first
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