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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678942/
Sep 10, 2008 · The promoter selectivity study further concluded that Pluronic block copolymers activated gene driven by p53 response element, which was not present in either of the promoters used . However, NFκB and p53 are engaged in a transcriptional cross talk with each other and …Author: Elena V. Batrakova, Alexander V. Kabanov, Alexander V. Kabanov
https://www.sciencedirect.com/science/article/pii/S0065266005530098
The evidence started to accumulate suggesting that these agents, in particular, Pluronic block copolymers, can increase gene expression in a way that does not fit the current non‐viral gene delivery paradigm. This chapter considers the current advances in …Author: Alexander Kabanov, Jian Zhu, Valery Alakhov
https://www.sciencedirect.com/science/article/abs/pii/S0168365902000093
Pluronic ® block copolymers are found to be an efficient drug delivery system with multiple effects. The incorporation of drugs into the core of the micelles formed by Pluronic ® results in increased solubility, metabolic stability and circulation time for the drug. The interactions of the Pluronic ® unimers with multidrug-resistant cancer cells result in sensitization of these cells with ...Author: Alexander V Kabanov, Elena V Batrakova, Valery Yu Alakhov
https://www.researchgate.net/publication/7523628_Pluronic_Block_Copolymers_for_Gene_Delivery
Therefore, there is substantial evidence that Pluronic block copolymers can improve gene expression with different delivery routes and different types of vectors, including naked DNA.
https://www.researchgate.net/publication/11210991_Pluronic_R_block_copolymers_as_novel_polymer_therapeutics_for_drug_and_gene_delivery
Pluronic (R) block copolymers as novel polymer therapeutics for drug and gene delivery Article · Literature Review in Journal of Controlled Release 82(2-3):189-212 · September 2002 with 118 Reads
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574534/
In this study we demonstrate for the first time that Pluronic enhances both cellular uptake and nuclear transport of pDNA delivered into cells with DNA/polycation complexes (“polyplexes”) and suggest that by combining Pluronic with existing non-viral vectors the efficiency of gene delivery can be safely increased.Author: Zhihui Yang, Gaurav Sahay, Srikanth Sriadibhatla, Alexander V. Kabanov
http://maroonbiotech.com/pdf/PluronicsforGeneTherapy.pdf
Pluronic block copolymers, which appear to be very valuable for gene delivery in skeletal muscle. Furthermore, Pluronic block copolymers have proven to be useful elements in polyplexes on the 3. Self-assembly of Pluronic block copolymers base of the polycation and DNA complexes that have a potential in a variety of gene therapy applications.
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)35828-2
May 01, 2012 · Introduction: Pluronics or poloxamers are non-ionic block copolymers used for in vivo non-viral gene delivery. When injected along with plasmid DNA these poloxamers (Pluronics) increase transgene expression in muscle and acts as an adjuvant to enhance immune response.
https://www.semanticscholar.org/paper/Pluronic-block-copolymers-as-novel-polymer-for-drug-Kabanov-Batrakova/f1f532a8f82a889188e8285fe1fea0ccff6391ac
Pluronic block copolymers are found to be an efficient drug delivery system with multiple effects. The incorporation of drugs into the core of the micelles formed by Pluronic results in increased solubility, metabolic stability and circulation time for the drug. The interactions of the Pluronic unimers with multidrug-resistant cancer cells result in sensitization of these cells with respect to ...
https://pubs.rsc.org/en/content/articlelanding/2014/ra/c4ra04308a#!
Synthesis and characterization of pluronic-block-poly(N,N-dimethylamino-2-ethyl methacrylate) pentablock copolymers for drug/gene co-delivery systems†
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