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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383223/
Insulin is the drug therapy for patients with insulin-dependent diabetes mellitus. A number of attempts have been made in the past to overcome the problems associated with the oral delivery of insulin, but with little success. Orally administered insulin ...Author: Sampath Malathi, Perumal Nandhakumar, Velayudham Pandiyan, Thomas J Webster, Sengottuvelan Balasubra...
https://www.ncbi.nlm.nih.gov/pubmed/28165858
PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro/in vivo studies. ... This article reports a promising approach to enhance the oral delivery of nuciferine (NUC), improve its aqueous solubility and bioavailability, and allow its controlled release as well as inhibiting lipid ...Author: Ying Liu, Xin Wu, Yushuai Mi, Bimeng Zhang, Shengying Gu, Gaolin Liu, Xiaoyu Li
https://www.sciencedirect.com/science/article/pii/S0927776517306872
1. Introduction. Polylactic-co-glycolic acid (PLGA) is a random copolymer of polylactic and polyglycolic acid .Due to its excellent bio-compatibility and biodegradability, PLGA is widely used as the matrices of drug delivery systems .Significantly, the PLGA has been approved by FDA for human therapy .As a amphipathic copolymer, PLGA can be developed into NPs easily .Author: Yongli Shi, Jintao xue, Liyun Jia, Qian Du, Jie Niu, Dongyang Zhang
https://www.tandfonline.com/doi/pdf/10.1080/10717544.2016.1261381
PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro/in vivo studies Ying Liu1*, Xin Wu1*, Yushuai Mi2*, Bimeng Zhang3, Shengying Gu1, Gaolin Liu1, and Xiaoyu Li1 1Department of Clinical Pharmacy, 2Department of General Surgery, and 3Department of Acupuncture and Moxibustion ...Author: Ying Liu, Xin Wu, Yushuai Mi, Bimeng Zhang, Shengying Gu, Gaolin Liu, Xiaoyu Li
https://www.sciencedirect.com/science/article/pii/S0022354916325497
PLGA Nanoparticles for Oral Delivery of Hydrophobic Drugs: Influence of Organic Solvent on Nanoparticle Formation and Release Behavior In Vitro and In Vivo Using Estradiol as a Model Drug. Author links open overlay panel D.K. Sahana 1 G. Mittal 1 V. Bhardwaj 1 …Author: D.K. Sahana, G. Mittal, V. Bhardwaj, M.N.V.Ravi Kumar
https://www.researchgate.net/publication/313416618_PLGA_nanoparticles_for_the_oral_delivery_of_nuciferine_preparation_physicochemical_characterization_and_in_vitro_in_vivo_studies
PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro / in vivo studies Article in Drug Delivery 24(1):443-451 · November 2017 with 24 ...
https://www.tandfonline.com/doi/abs/10.1080/10717544.2016.1261381
Feb 03, 2017 · AbstractThis article reports a promising approach to enhance the oral delivery of nuciferine (NUC), improve its aqueous solubility and bioavailability, and allow its controlled release as well as inhibiting lipid accumulation. NUC-loaded poly lactic-co-glycolic acid nanoparticles (NUC-PLGA-NPs) were prepared according to a solid/oil/water (s/o/w) emulsion technique due to the water ...Author: Ying Liu, Xin Wu, Yushuai Mi, Bimeng Zhang, Shengying Gu, Gaolin Liu, Xiaoyu Li
https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.8b00809
The oral absorption of exenatide, a drug for type 2 diabetes treatment, can be improved by using nanoparticles (NPs) for its delivery. To improve the mucus penetration and intestinal absorption of exenatide, we designed a block copolymer, CSKSSDYQC-dextran-poly(lactic-co-glycolic acid) (CSK-DEX-PLGA), and used it for the preparation of exenatide-loaded NPs. The functionalized exenatide …Author: Yina Song, Yanan Shi, Liping Zhang, Haiyan Hu, Chunyan Zhang, Miaomiao Yin, Liuxiang Chu, Xiuju Yan,...
https://www.researchgate.net/publication/225289524_Novel_preparation_of_PLGAHP55_nanoparticles_for_oral_insulin_delivery
The aim of the present study was to develop the PLGA/HP55 nanoparticles with improved hypoglycemic effect for oral insulin delivery. The insulin-loaded PLGA/HP55 nanoparticles were produced by a ...
https://www.nature.com/articles/s41598-018-19170-y
Jan 15, 2018 · To improve the oral efficiency of exenatide, we prepared polyethylene glycol-poly(lactic-co-glycolic acid) (PEG-PLGA) NPs modified with Fc (NPs-Fc) for exenatide oral delivery. Exenatide was ...Author: Yanan Shi, Xinfeng Sun, Liping Zhang, Kaoxiang Sun, Keke Li, Youxin Li, Qiang Zhang
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