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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660441/
Feb 09, 2009 · Quantitative studies indicated that presence of PEI in PLGA nanoparticles resulted in 2-fold higher cellular uptake of nanoparticles while fluorescence microscopy studies showed that PLGA-PEI nanoparticles delivered the encapsulated siRNA in the cellular cytoplasm; both higher uptake and greater cytosolic delivery could have contributed to the gene silencing effectiveness of PLGA-PEI nanoparticles.Author: Yogesh Patil, Yogesh Patil, Jayanth Panyam
https://www.sciencedirect.com/science/article/pii/S0142961211011379
We have developed PLGA-based nanoparticles that provide targeted and efficient delivery of siRNA. These nanoparticles are truly multifunctional and offer several advantages over other technologies for siRNA delivery. First, PLGA, the major biomaterial used in this nanoparticle synthesis, has been safely used in clinical applications for many decades.Author: Jiangbing Zhou, Toral R. Patel, Michael Fu, James P. Bertram, W. Mark Saltzman
https://pubs.acs.org/doi/abs/10.1021/nn300106t
Composite nanofibers of biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) encapsulating chitosan/siRNA nanoparticles (NPs) were prepared by electrospinning. Acidic/alkaline hydrolysis and a bulk/surface degradation mechanism were investigated in order to achieve an optimized release profile for prolonged and efficient gene silencing.Author: Menglin Chen, Shan Gao, Mingdong Dong, Jie Song, Chuanxu Yang, Kenneth Alan Howard, Jørgen Kjems, Fl...
https://www.nature.com/articles/s41598-018-25930-7
May 14, 2018 · Herein, we synthesized PLGA nanoparticles (PLGA NPs) as a co-delivery nanocarrier for MDR1 and BCL2 siRNA by using poly-L-lysine (PPL) as a complexing reagent, and demonstrated that siRNA-loaded...Author: Chitra Risnayanti, Chitra Risnayanti, Yeong-Su Jang, Jinju Lee, Hyung Jun Ahn
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204797/
We have developed PLGA-based nanoparticles that provide targeted and efficient delivery of siRNA. These nanoparticles are truly multifunctional and offer several advantages over other technologies for siRNA delivery. First, PLGA, the major biomaterial used in this nanoparticle synthesis, has been safely used in clinical applications for many decades.Author: Jiangbing Zhou, Toral R. Patel, Michael Fu, James P. Bertram, W. Mark Saltzman
https://www.nature.com/articles/srep46250
Apr 07, 2017 · PLGA-based dual targeted nanoparticles enhance miRNA transfection efficiency in hepatic carcinoma. ... L. Tumor-targeted delivery of siRNA by …Author: Chenlei Cai, Yuexia Xie, liangliang Wu, Xiaojing Chen, Hongmei Liu, Yan Zhou, Hanbing Zou, Dejun Liu...
https://www.researchgate.net/publication/23402893_Polymeric_Nanoparticles_for_siRNA_Delivery_and_Gene_Silencing
In the present study, we investigated nanoparticles formulated using the biodegradable polymer, poly(d,l-lactide-co-glycolide) (PLGA) for siRNA delivery. A cationic polymer, polyethylenimine (PEI),...
https://www.sciencedirect.com/science/article/pii/S0939641110002973
In particular, PLGA nanoparticles have attracted much attention since they are assumed to meet the criteria required for successful siRNA delivery: (i) They are sufficiently small for efficient tissue penetration and cellular uptake, (ii) the siRNA can be entrapped into the PLGA matrix, which offers physical protection against RNase activity as well as a favorable colloidal stability of the system, and (iii) the PLGA …Author: Dongmei Cun, Ditte Krohn Jensen, Morten Jonas Maltesen, Matthew Bunker, Paul Whiteside, David Scurr,...
https://www.cell.com/molecular-therapy-family/methods/fulltext/S2329-0501(16)30165-6
Jan 01, 2016 · Gene therapy is a promising strategy for specific treatment of numerous gene-associated human diseases by intentionally altering the gene expression in pathological cells. A successful clinical application of gene-based therapy depends on an efficient gene delivery system. Many efforts have been attempted to improve the safety and efficiency of gene-based therapies. Nanoparticles have been ...Author: Jie Chen, Zhaopei Guo, Huayu Tian, Xuesi Chen
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