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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312337/
PLGA Nanoparticles for Ultrasound-Mediated Gene Delivery to Solid Tumors 1. Introduction. To achieve successful gene therapy in a clinical setting,... 2. Current Sonoporation Principles. A relatively novel strategy for gene... 3. Echogenic Nanoparticles. In this paper, nanoparticles... 4. Novel ...Author: Marxa Figueiredo, Rinat Esenaliev
https://www.sciencedirect.com/science/article/pii/S0939641104000475
PLGA nanoparticles were shown to escape from the endo-lysosomal compartment to the cytoplasmic compartment and release their contents over extended periods of time , . These properties rendered PLGA nanoparticles as potential efficient sustained release gene delivery systems.Author: Maytal Bivas-Benita, Stefan Romeijn, Hans E. Junginger, Gerrit Borchard
https://www.sciencedirect.com/science/article/abs/pii/S0939641104000475
Pulmonary gene delivery is thought to play an important role in treating genetically related diseases and may induce immunity towards pathogens entering the body via the airways. In this study we prepared poly ( d , l -lactide- co -glycolide) (PLGA) nanoparticles bearing polyethyleneimine (PEI) on their surface and characterized them for their potential in serving as non-viral gene carriers to the pulmonary …Author: Maytal Bivas-Benita, Stefan Romeijn, Hans E. Junginger, Gerrit Borchard
https://www.sciencedirect.com/science/article/pii/S1549963407000895
To study the ability of chitosan-coated PLGA nanoparticles as a carrier for gene delivery, nanoparticles were loaded with the antisense oligonucleotide, OMR. The cationic nanoparticles were mixed with a solution of the oligonucleotides at room temperature and vortexed for 30 seconds followed by incubation on an orbital shaker at room temperature.Author: Noha Nafee, Noha Nafee, Sebastian Taetz, Marc Schneider, Ulrich F. Schaefer, Claus-Michael Lehr
https://www.sciencedirect.com/science/article/pii/S0169409X02002284
2.4. Therapeutic applications of PLGA nanoparticles 2.4.1. Sustained gene delivery. Rapid escape of nanoparticles from the degradative endo-lysosomal... 2.4.2. Protein delivery. Therapeutic proteins and peptides can be encapsulated into nanoparticles... 2.4.3. Vaccine adjuvant. Nano- and ...Author: Jayanth Panyam, Vinod D Labhasetwar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087123/
Keywords: Surface engineering, Lipids, PLGA nanoparticle, Self assembly, Cell membrane derived lipid vesicles, Biomimetic fucntionalization, Controlled drug release, Gene delivery Background Nanotechnology has been widely studied to improve the pharmacokinetics and therapeutic efficacy of a myriad of drugs, including proteins, genes, and other small molecules [ 1 – 4 ].Author: Rajendran Jc Bose, Soo-Hong Lee, Hansoo Park
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