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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846924/
Feb 15, 2016 · Neurological disorders are an important global public health problem, but pharmaceutical treatments are limited due to drug access to the central nervous system being restricted by the blood-brain barrier (BBB). Poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) are one of the most promising drug and gene delivery systems for crossing the ...Author: Qiang Cai, Long Wang, Gang Deng, Junhui Liu, Qianxue Chen, Zhibiao Chen
https://www.sciencedirect.com/science/article/pii/S0378517311005102
Aug 30, 2011 · A novel Lf-NP brain drug delivery system was constructed by conjugation of biodegradable PEG-PLGA nanoparticles with Lf, a promising brain targeting molecule. The activity of the conjugated Lf was validated by the existence of gold-labeled Lf …Author: Kaili Hu, Kaili Hu, Yanbin Shi, Wenming Jiang, Jiaying Han, Shixian Huang, Xinguo Jiang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539329/
Brain delivery with PBCA nanoparticles. Adsorbed onto polysorbate 80-coated PBCA nanoparticles administered intravenously compounds with poor brain diffusion as diverse as doxorubicin, 25, 26 loperamide, 27 tubocurarine, 28 the hexapeptide dalargin 6, 7 were successfully delivered to the brain, where they induced a pharmacological effect (for review, see Kreuter 29).Author: Jean-Christophe Olivier
https://www.sciencedirect.com/science/article/pii/S0928098713000341
The aim of this study was to develop novel multiple agents loaded poly (d, l-lactide-co-glycolide acid) (PLGA) nanoparticles (NPs) and evaluate their potential for brain delivery via inner ear administration.PLGA NPs loaded with salvianolic acid B (Sal B), tanshinone IIA (TS IIA) and panax notoginsenoside (PNS) were prepared by double emulsion/solvent evaporation method.Author: Xiao Zhang, Gang Chen, Lu Wen, Fan Yang, A-li Shao, Xia Li, Wei Long, Lei Mu
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-020-0585-9
The aims of the present study were to first develop a method for embedding minocycline-loaded PLGA nanoparticles into non-crosslinked gelatin-coatings and then to clarify whether the addition of the minocycline-loaded PLGA nanoparticles can mitigate the acute brain tissue responses.Author: Alexander Dontsios Holmkvist
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