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https://www.ncbi.nlm.nih.gov/pubmed/12769666
In developing a drug delivery strategy, issues of absorption, distribution, metabolism, and elimination must be considered. The eye presents unique opportunities and challenges when it comes to the delivery of pharmaceuticals, and is most accessible to the application of topical medications.Author: Steven B. Koevary
https://www.liebertpub.com/doi/10.1089/jop.1986.2.67
The design of ocular drug delivery systems is undergoing a gradual transition from an empirical to a rational base. This is partly due to a better understanding of the constraints on drug disposition in the eye and partly due to improved approaches in animal and clinical assessment of ocular drugs and drug delivery systems.Author: Vincent H.L. Lee, Joseph R. Robinson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1389-2002&volume=4&issue=3&spage=213
Keywords:topical ocular drug delivery, posterior segment disease, topical medications, intraocular environment, nepafenac, retinal neovascularization. Abstract: In developing a drug delivery strategy, issues of absorption, distribution, metabolism, and elimination must be considered. The eye presents unique opportunities and challenges when it ...Author: Steven B. Koevary
https://www.sciencedirect.com/science/article/pii/S0169409X06001578
Ocular pharmacokinetics and drug delivery issues werel shortly described. It is evident that there are major obstacles in ocular pharmacokinetics. Overcoming these barriers should help in the development of improved drug delivery systems to treat conditions with currently unmet medical need.Author: Arto Urtti
https://www.researchgate.net/publication/311451268_Pharmacokinetics_and_Pharmacodynamics_of_Ocular_Drugs
The focus of this review is on recent developments in topical ocular drug delivery systems relative to their success in overcoming the constraints imposed by the eye and to the improvements that ...
https://www.tandfonline.com/doi/abs/10.1080/10717544.2018.1458923
Apr 16, 2018 · In addition, the in vivo pharmacokinetics profile showed that the CsA-loaded micelles could enhance the retention time, achieving longer effect toward the DES. These studies proposed an effective micelle formulation as a novel ocular drug delivery system to improve solubility and bioavailability of ophthalmic CsA-controlled delivery.Author: Yinglan Yu, Daquan Chen, Yanan Li, Wenqian Yang, Jiasheng Tu, Yan Shen
https://plasticsurgerykey.com/pharmacokinetics-and-topical-applications-of-drugs/
Pharmacokinetics related to topical applications of drugs describes the time-dependent drug concentration following the application of the drug to the skin surface, its subsequent passage through the skin barrier into the underlying skin layers, and its distribution into the systemic circulation.
https://www.slideshare.net/jeevanjacob11/ocular-pharmacokinetics
Jan 03, 2015 · OCULAR PHARMACOKINETICS,ROUTES OF DRUG ADMINISTRATION Dr. Jeevan Jacob Junior Resident Dept. Of Pharmacology ... APPROACHES TO IMPROVE TOPICAL DELIVERY OF DRUGS 1. To prolong the contact time of drug with corneal surface 2. ... CONCLUSION & FUTURE OUTLOOK Ocular drug delivery has to overcome unique barriers. Development of ophthalmic drug ...
https://www.liebertpub.com/doi/10.1089/jop.2017.0099
Jun 01, 2018 · Hence, the use of topical formulations of LPs, instead of intravitreal injections for drug delivery in ocular diseases of the posterior segment, could result in an accessible and safer therapy, since neither special infrastructure nor trained professionals are required for its administration.Author: C Altamirano-VallejoJuan, Navarro-PartidaJose, Gonzalez-De la RosaAlejandro, H HsiaoJane, S Olguín-G...
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