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https://www.ncbi.nlm.nih.gov/pubmed/27798766
Several pharmacokinetics compartment models of ocular drug delivery have been developed for describing the absorption, distribution, and elimination of ocular drugs in the eye. Determining pharmacokinetics parameters in ocular tissues is a major challenge because of the complex anatomy and dynamic physiological barrier of the eye.Author: Vibhuti Agrahari, Abhirup Mandal, Vivek Agrahari, Vivek Agrahari, Hoang M. Trinh, Mary Joseph, Animi...
https://www.sciencedirect.com/science/article/pii/S0169409X06001578
Ocular pharmacokinetics and drug delivery issues werel shortly described. It is evident that there are major obstacles in ocular pharmacokinetics. Overcoming these barriers should help in the development of improved drug delivery systems to treat conditions with currently unmet medical need.Author: Arto Urtti
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers (different layers of cornea, sclera, and retina including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps in conjunction pose a ...Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
https://www.slideshare.net/jeevanjacob11/ocular-pharmacokinetics
Jan 03, 2015 · Ocular pharmacokinetics 1. OCULAR PHARMACOKINETICS,ROUTES OF DRUG ADMINISTRATION Dr. Jeevan Jacob Junior Resident Dept. Of Pharmacology 2. INTRODUCTION Ocular administration of drug is primarily associated with the need to treat ophthalmic diseases.
https://www.sciencedirect.com/science/article/pii/S1359644618303994
Ocular drug delivery is a field in which regular ADME tools are not useful. • Pharmacokinetics based dosing aid for ocular drug delivery is presented. • User-friendly dosing aid guides early stage design of delivery systems. • Guidance for the delivery route, dosing and formulation design is presented.Author: Astrid Subrizi, Astrid Subrizi, Eva M. del Amo, Viktor Korzhikov-Vlakh, Tatiana Tennikova, Marika Ru...
https://www.arvo.org/globalassets/annual-meeting/program/education-courses/2020-agenda---ocular-drug-delivery.pdf
Ocular drug delivery: Fundamentals, challenges, and technologies Organizers Ash Jayagopal, PhD, Kodiak Sciences Inc. and Uday Kompella, PhD, University of Colorado, Anschutz Medical Campus Description Ocular drug delivery is an evolving field featuring cutting-edge advances in devices, formulations, and paradigms for design and characterization.
https://www.researchgate.net/publication/311451268_Pharmacokinetics_and_Pharmacodynamics_of_Ocular_Drugs
There are many new and innovative advances in ocular drug delivery due to better understanding of the structure and function of the eye, the nature of its diseases, and how to overcome or utilize ...
https://www.researchgate.net/publication/308134789_Ocular_drug_delivery_and_pharmacokinetics_influence_of_drug_properties_and_delivery_systems
Request PDF Ocular drug delivery and pharmacokinetics: influence of drug properties and delivery systems Although the eye is readily accessible for drug dosing, drug delivery to the eye ...
http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1389-2002&volume=4&issue=3&spage=213
Keywords:topical ocular drug delivery, posterior segment disease, topical medications, intraocular environment, nepafenac, retinal neovascularization. Abstract: In developing a drug delivery strategy, issues of absorption, distribution, metabolism, and elimination must be considered. The eye presents unique opportunities and challenges when it ...Author: Steven B. Koevary
https://link.springer.com/10.1007/s11095-018-2498-y
Sep 25, 2018 · The development of ophthalmic drug delivery systems is a long and comprehensive process including research, nonclinical, and clinical development stages. It is critical to understand the similarity and differences between animal models and patients. There are many anatomically and physiologically important parameters for targeted drug delivery into eyes. This paper reviews the …Author: Jie Shen, Guang Wei Lu, Patrick Hughes
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