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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830889/
In order to devise a novel podocyte specific siRNA delivery system, we developed an antibody that would specifically bind to podocytes. Accordingly, fully differentiated immortalized podocytes (3–5×10 6 cells) were combined with complete Freund's adjuvant (2 ml) for the first immunization of a sheep. Incomplete Freund's adjuvant was used for subsequent immunizations and administered to the sheep …Author: Peter V. Hauser, Jeffrey W. Pippin, Cora Kaiser, Ronald D. Krofft, Paul T. Brinkkoetter, Kelly L. Hu...
https://ashpublications.org/blood/article/113/12/2646/25005/A-novel-in-vivo-siRNA-delivery-system-specifically
Herein, we have shown, for the first time, a novel cell-specific in vivo delivery system for siRNA by modifying liposomal approaches. 12-16 Our novel approach, which we termed siRNA immunoliposomes (siILs), demonstrated a potent and long-lasting cell-specific gene-silencing efficiency and can potentially increase the feasibility of RNAi therapy in clinical application.Author: Xiufen Zheng, Xiufen Zheng, Costin Vladau, Xusheng Zhang, Xusheng Zhang, Motohiko Suzuki, Thomas E. ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727148/
Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy Jiehua Zhou , 1 Haitang Li , 1 Shirley Li , 2 John Zaia , 2 and John J Rossi 1 1 Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, California, USAAuthor: Jiehua Zhou, Haitang Li, Shirley Li, John Zaia, John J Rossi
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.356.1407
The delivery system was named shamporter (sheep anti mouse podocyte transporter). Injection of shamporter coupled with either nephrin siRNA or TRPC6 siRNA via tail vein into normal rats substantially reduced the protein levels of nephrin or TRPC6 respectively, measured by …
https://www.ncbi.nlm.nih.gov/pubmed/20209128
Mar 01, 2010 · The delivery system was named shamporter (sheep anti mouse podocyte transporter). Injection of shamporter coupled with either nephrin siRNA or TRPC6 siRNA via tail vein into normal rats substantially reduced the protein levels of nephrin or TRPC6 respectively, measured by western blot analysis and immunostaining.Author: Peter V. Hauser, Jeffrey W. Pippin, Cora Kaiser, Ronald D. Krofft, Paul T. Brinkkoetter, Kelly L. Hu...
https://pubs.rsc.org/en/content/articlelanding/2017/tb/c7tb01068k
Black phosphorus quantum dot based novel siRNA delivery systems in human pluripotent teratoma PA-1 cells. Feng Yin, a Kuan Hu, a Si Chen, b Dongyuan Wang, a Jianing Zhang, a Mingsheng Xie, a Dan Yang, a Meng Qiu, b Han Zhang* b and Zi-gang Li* a.Author: Feng Yin, Kuan Hu, Si Chen, Dongyuan Wang, Jianing Zhang, Mingsheng Xie, Dan Yang, Meng Qiu, Han Zha...
https://www.sigmaaldrich.com/catalog/papers/20209128
The delivery system was named shamporter (sheep anti mouse podocyte transporter). Injection of shamporter coupled with either nephrin siRNA or TRPC6 siRNA via tail vein into normal rats substantially reduced the protein levels of nephrin or TRPC6 respectively, measured by …
https://cancerres.aacrjournals.org/content/74/19_Supplement/479
Oct 01, 2014 · To address these shortcomings, Mirus Bio has developed a novel non-liposomal technology called the TransIT-X2™ Dynamic Delivery System. This unique polymeric delivery system is able to effectively condense negatively charged nucleic acids (plasmid DNA and/or siRNA), enter cells and break out of the endosomal compartment, a critical barrier ...Author: James Ludtke, Anthony Lauer, Austin Storck, Nicholas Rossi, Karen Neder, Anatoly Pinchuk, Laura Juck...
https://www.researchgate.net/publication/41809743_Novel_siRNA_Delivery_System_to_Target_Podocytes_In_Vivo
The delivery system was named shamporter (sheep anti mouse podocyte transporter). Injection of shamporter coupled with either nephrin siRNA or TRPC6 siRNA via tail vein into normal rats substantially reduced the protein levels of nephrin or TRPC6 respectively,...
https://www.ncbi.nlm.nih.gov/pubmed/22970170
A novel in vivo siRNA delivery system specifically targeting liver cells for protection of ConA-induced fulminant hepatitis. Jiang N(1), Zhang X, Zheng X, Chen D, Siu K, Wang H, Ichim TE, Quan D, McAlister V, Chen G, Min WP. Author information: (1)Multi-Organ Transplant Program, London Health Sciences Centre, London, Ontario, CanadaAuthor: Nan Jiang, Nan Jiang, Nan Jiang, Xusheng Zhang, Xusheng Zhang, Xiufen Zheng, Xiufen Zheng, Di Chen, ...
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