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https://www.researchgate.net/publication/236006801_Prodrug_Approach_to_Better_Drug_Delivery
Prodrug: Approach to Better Drug Delivery. ... dedicated to using prodrugs for the delivery of older but problematic drugs as well as to developing broad-based prodrug technologies for application ...
https://www.sciencedirect.com/topics/nursing-and-health-professions/drug-delivery-system
Drug Delivery System. A drug delivery system (DDS) is defined as a formulation or a device that enables the introduction of a therapeutic substance into the body and improves its efficacy and safety by controlling the rate, time, and place of release of drugs in the body.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590725/
Jan 23, 2014 · In this review, the strategies that have been employed to develop kidney-targeted drug delivery systems were summarized and how macromolecular carriers and prodrugs play crucial roles in targeting drugs to particular target cells in the kidney was described.Author: Peng Zhou, Xun Sun, Zhirong Zhang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751454/
Feb 05, 2008 · Central nervous system (CNS) drug delivery remains a major challenge, despite extensive efforts that have been made to develop novel strategies to overcome obstacles. Prodrugs are bioreversible derivatives of drug molecules that must undergo an enzymatic ...Author: Jarkko Rautio, Krista Laine, Mikko Gynther, Jouko Savolainen
https://www.researchgate.net/publication/286803656_Prodrugs_and_Drug_Delivery_Systems
Prodrugs and Drug Delivery Systems. ... In this study the advantages of micellar prodrugs as water-soluble delivery systems for parenteral administration of relatively insoluble parent drugs are ...
https://www.sciencedirect.com/topics/neuroscience/prodrugs
S. Narasimha Murthy, H.N. Shivakumar, in Handbook of Non-Invasive Drug Delivery Systems, 2010. 1.4.3 Prodrug approach. Prodrugs have been utilized to enhance the dermal and transdermal permeation of drugs with unfavorable partition coefficients (Sloan, 1989).The prodrug approach involves addition of a promoiety to increase the partition coefficient and hence the permeation of the parent ...
https://journals.lww.com/americantherapeutics/Abstract/2012/01000/Recent_Advances_in_Prodrugs_as_Drug_Delivery.9.aspx
, the synthesis of prodrugs is usually much less difficult than the synthesis of analogs. The derived physicochemical properties of the resulting derivatives can be carefully tailored by means of structural modification of the promoiety. However, sufficient levels of intrinsic activity of the parent drug need to be assured through in vivo cleavage of the prodrug. The prodrug approach has been ...
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