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https://www.nature.com/articles/srep44929
Mar 21, 2017 · In this study, we demonstrated a novel genetic engineering strategy to enhance the efficacy and safety of phage-based delivery systems by integrating CRISPR/Cas9 system …Author: Joo Youn Park, Bo Youn Moon, Bo Youn Moon, Juw Won Park, Justin A. Thornton, Yong Ho Park, Keun Seok...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995314/
May 11, 2016 · Development of novel drug delivery systems using phage display technology for clinical application of protein drugs. ... drug delivery system, phage antibody technology, ... option for managing chronic inflammatory diseases and that our site-specific PEGylation system will become a standard technology for clinical application of protein drugs.Author: Kazuya Nagano, Yasuo Tsutsumi
https://www.sciencedirect.com/science/article/pii/S0378517319308956
Cpl-1, an endolysin derived from Cp-1 phage has been found to be effective in a number of in-vitro and in-vivo pneumococcal infection models. However its lower bioavailability under in-vivo conditions limits its applicability as therapeutic agent. In this study, Cpl-1 loaded chitosan nanoparticles were set up in order to develop a novel therapeutic delivery system to counter antibiotic ...Author: Vijay Singh Gondil, Taru Dube, Jiban J. Panda, Ragothaman M. Yennamalli, Kusum Harjai, Sanjay Chhibb...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579803/
Bead-encapsulation represents a simple inexpensive phage oral drug delivery system suitable for on farm applications directed to control the intestinal colonization of zoonotic and pathogenic bacteria. Further studies have the potential to combine nutritional and therapeutic components with phages to …Author: Abdallah S. Abdelsattar, Fatma Abdelrahman, Alyaa Dawoud, Ian F. Connerton, Ayman El-Shibiny
https://www.sciencedirect.com/science/article/pii/S000186861630392X
Phage resistant mutants were not found even in animals that had died. Intraperitoneal delivery of phage was found to result in delivery of higher phage dose, delivered earlier into the blood and other tissues, and delivered for a more sustained period of time.Author: Danish J. Malik, Ilya J. Sokolov, Gurinder K. Vinner, Francesco Mancuso, Salvatore Cinquerrui, Goran...
http://perspectivesinmedicine.cshlp.org/content/4/1/a012518.full
(4) Phage as a DNA delivery vehicle where antigen genes are cloned in phage genome under the control of eukaryotic promoters. (5) Phage for DNA vaccine, where phage carries antigen genes under the control of eukaryotic promoters.
https://mediphagelab.com/
Nucleic acid delivery vectors and production systems. The bacteriophage PY54 Tel/pal recombinase system has been exploited as a novel platform for the efficient production of linear covalently closed (LCC) DNA minivectors, termed DNA ministrings, to serve as safe and effective DNA delivery vectors.
https://www.sciencedaily.com/releases/2018/07/180717094813.htm
Jul 17, 2018 · Technique may improve lung delivery of bacteria-killing phage Date: July 17, 2018 Source: Georgia Institute of Technology Summary: A new delivery system for bacteriophages -- viruses that ...
https://mediphagelab.com/lytic-phage-display
New and surprising applications of phage display are emerging, including the display of a diverse set of peptides, to clinical applications including vaccine delivery. We have generated a novel system of phage display that is tune-able, which can prove very important in design, based on the therapeutic application.
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