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https://www.ncbi.nlm.nih.gov/pubmed/16296723
Periocular routes exploit the permeability of sclera for retinal drug delivery, and they are particularly useful for administering sustained-release systems of potent drugs. This review discusses the various periocular routes with respect to their anatomical location, pharmacokinetics, safety and mechanisms of drug delivery.Author: Swita Raghava, Makena Hammond, Uday B Kompella
https://www.tandfonline.com/doi/abs/10.1517/17425247.1.1.99
Mar 03, 2005 · Periocular routes for retinal drug delivery. Despite numerous scientific efforts, delivery of therapeutic amounts of a drug to the retina remains a challenge. This challenge is compounded if chronic therapy is desired. The inability or inefficiency of topical and systemic routes for retinal delivery of existing drugs is now widely accepted.Author: Swita Raghava, Makena Hammond, Uday B Kompella
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010371/
Jun 18, 2018 · Periocular pathways used for retinal drug delivery include four sub-routes: the subconjunctival, retrobulbar, peribulbar, and sub-tenon routes. The subconjunctival space is closest to the outside of the eyeball while the retrobulbar site is behind the eyeball. The sub-tenon and peribulbar spaces are between them, along with the orbit.Author: Sibo Jiang, Yesenia L Franco, Yan Zhou, Jianjun Chen
https://www.researchgate.net/publication/7471348_Periocular_routes_for_retinal_drug_delivery
Periocular routes exploit the permeability of sclera for retinal drug delivery, and they are particularly useful for administering sustained-release systems of potent drugs. This review discusses the various periocular routes with respect to their anatomical location, pharmacokinetics,...
https://www.sciencedirect.com/science/article/pii/S1350946216300635
Retinal drug delivery could also be accomplished using other methods, such as systemic, topical, periocular (sub-conjunctival, sub-Tenon's, posterior juxtascleral, peribulbar and retrobulbar injections), sub-retinal and suprachoroidal drug administration , but these approaches may not result in adequate drug concentrations in the retina with currently available technologies. These routes of drug delivery may become clinically feasible if new improved drug delivery …Author: Eva M. del Amo, Anna-Kaisa Irmeli Rimpelä, Emma Heikkinen, Otto K. Kari, Eva Ramsay, Tatu Lajunen, M...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061492/
Periocular Drug Delivery Routes. Periocular drug delivery using the transscleral absorption pathway is one of the safest means of achieving consistent therapeutic drug concentrations in the inner coat of the posterior segment (Table 1). 5,6,24 Periocular drug delivery systems, however, require drugs to pass through several layers of ocular tissue (episclera, sclera, choroid, Bruch's membrane, and RPE) to reach the retina …Author: Henry F. Edelhauser, Cheryl L. Rowe-Rendleman, Michael R. Robinson, Daniel G. Dawson, Gerald J. Chad...
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