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https://www.ncbi.nlm.nih.gov/pubmed/16296723
Periocular routes exploit the permeability of sclera for retinal drug delivery, and they are particularly useful for administering sustained-release systems of potent drugs. This review discusses the various periocular routes with respect to their anatomical location, pharmacokinetics, safety and mechanisms of drug delivery.Author: Swita Raghava, Makena Hammond, Uday B Kompella
https://www.tandfonline.com/doi/abs/10.1517/17425247.1.1.99
Mar 03, 2005 · Periocular routes for retinal drug delivery. Despite numerous scientific efforts, delivery of therapeutic amounts of a drug to the retina remains a challenge. This challenge is compounded if chronic therapy is desired. The inability or inefficiency of topical and systemic routes for retinal delivery of existing drugs is now widely accepted.Author: Swita Raghava, Makena Hammond, Uday B Kompella
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010371/
Jun 18, 2018 · Periocular pathways used for retinal drug delivery include four sub-routes: the subconjunctival, retrobulbar, peribulbar, and sub-tenon routes. The subconjunctival space is closest to the outside of the eyeball while the retrobulbar site is behind the eyeball. The sub-tenon and peribulbar spaces are between them, along with the orbit.Author: Sibo Jiang, Yesenia L Franco, Yan Zhou, Jianjun Chen
https://www.researchgate.net/publication/7471348_Periocular_routes_for_retinal_drug_delivery
Periocular routes exploit the permeability of sclera for retinal drug delivery, and they are particularly useful for administering sustained-release systems of potent drugs.
https://www.sciencedirect.com/science/article/pii/S1359644618303945
The periocular space is a promising alternative route for the delivery of drugs to the posterior eye segment, especially when treating conditions in the outer ocular layers. In this review, we discuss the different periocular routes as well as the physiological barriers and elimination mechanisms limiting drug bioavailability at the back of the eye.Author: Yosra Agban, Sachin S. Thakur, Odunayo O. Mugisho, Ilva D. Rupenthal
https://www.sciencedirect.com/science/article/pii/S1350946216300635
The delivery of drugs to retinal targets is challenging and various routes of drug administration have been investigated . Unfortunately, most of them result in sub-therapeutic drug levels in the retina. Intravitreal injection is currently the method of choice in retinal drug delivery . Intravitreal injections are used widely in the clinics, especially in the delivery of anti-VEGF proteins (bevacizumab, ranibizumab, …Author: Eva M. del Amo, Anna-Kaisa Irmeli Rimpelä, Emma Heikkinen, Otto K. Kari, Eva Ramsay, Tatu Lajunen, M...
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