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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059050/
Here, we describe the use of polymeric vectors, in particular biodegradable poly (β-amino esters) (PBAEs), for non-viral gene delivery. These polymers are able to self-assemble with DNA and form positively charged gene delivery nanoparticles. Methods for synthesis of these polymers…Author: Jordan J. Green, Gregory T. Zugates, Robert Langer, Daniel G. Anderson
https://www.ncbi.nlm.nih.gov/pubmed/19085119
Poly(beta-amino esters): procedures for synthesis and gene delivery. Green JJ(1), Zugates GT, Langer R, Anderson DG. Author information: (1)Department of Biological Engineering, Department of Chemical Engineering, and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Author: Jordan J. Green, Gregory T. Zugates, Robert Langer, Daniel G. Anderson
https://link.springer.com/protocol/10.1007%2F978-1-59745-429-2_4
Sep 30, 2008 · Poly(β-amino esters): Procedures for Synthesis and Gene Delivery. Summary. Non-viral gene delivery systems are promising as they avoid many problems of viral gene therapy by having increased design flexibility, high safety, large DNA cargo capacity, and ease of manufacture.Author: Jordan J. Green, Gregory T. Zugates, Robert Langer, Daniel G. Anderson
https://jhu.pure.elsevier.com/en/publications/polybeta-amino-esters-procedures-for-synthesis-and-gene-delivery-2
title = "Poly(beta-amino esters): procedures for synthesis and gene delivery.", abstract = "Non-viral gene delivery systems are promising as they avoid many problems of viral gene therapy by having increased design flexibility, high safety, large DNA cargo capacity, and ease of manufacture.Author: Jordan J. Green, Gregory T. Zugates, Robert Langer, Daniel G. Anderson
https://europepmc.org/articles/PMC4059050
Jan 01, 2009 · Poly(beta-amino esters): procedures for synthesis and gene delivery. Jordan J Green Department of Biological Engineering, Department of Chemical Engineering, and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.Author: Jordan J. Green, Gregory T. Zugates, Robert Langer, Daniel G. Anderson
https://www.researchgate.net/publication/23665888_Polyb-amino_esters_Procedures_for_Synthesis_and_Gene_Delivery
Poly (β-amino esters) (PBAEs) are another class of cationic polymer that were designed to meet specific criteria for gene delivery, including DNA condensation, biodegradability, and minimal cytotoxicity [88], PBAEs may contain different types of amines and can be synthesized...
https://pubs.acs.org/doi/full/10.1021/acs.biomac.5b00966
Highly branched poly(β-amino esters) (HPAEs) are developed via a facile and controllable “A2+B3/B2” strategy successfully. As nonviral gene delivery vectors, the performance of HPAEs is superior to the well-studied linear counterpart as well as the leading commercial reagent Superfect. When combined with minicircle DNA construct, HPAEs can achieve ultrahigh gene transfection efficiency ...Author: Lara Cutlar, Dezhong Zhou, Yongsheng Gao, Tianyu Zhao, Udo Greiser, Wei Wang, Wenxin Wang
https://pubs.acs.org/doi/abs/10.1021/acs.biomac.5b00966
Highly branched poly(β-amino esters) (HPAEs) are developed via a facile and controllable “A2+B3/B2” strategy successfully. As nonviral gene delivery vectors, the performance of HPAEs is superior to the well-studied linear counterpart as well as the leading commercial reagent Superfect.Author: Lara Cutlar, Dezhong Zhou, Yongsheng Gao, Tianyu Zhao, Udo Greiser, Wei Wang, Wenxin Wang
https://www.sciencedirect.com/science/article/pii/S014296121100398X
Synthesis of poly(β-amino esters) PBAEs were synthesized in a two-step reaction as described previously [14] using small commercially-available molecules ( Fig. 1 ). These small molecules were purchased from Acros Organics (E8), Alfa Aesar (B4, B6, S3, S4, S5, E7), Fluka (E6), Monomer–Polymer and Dajac Labs (B5), Sigma–Aldrich (E9), and TCI America (E3, E4, E5), and …Author: Stephany Y. Tzeng, Hugo Guerrero-Cázares, Elliott E. Martinez, Joel C. Sunshine, Alfredo Quiñones-Hi...
https://advances.sciencemag.org/content/5/12/eaay3255.full
Dec 01, 2019 · Current methods of protein delivery often suffer from low serum tolerance and limited in vivo efficacy. Here, we report the synthesis and validation of a previously unreported class of carboxylated branched poly(β-amino ester)s that can self-assemble into nanoparticles for efficient intracellular delivery of a variety of different proteins.Author: Yuan Rui, David R. Wilson, John Choi, Mahita Varanasi, Katie Sanders, Johan Karlsson, Michael Lim, J...
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