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https://www.researchgate.net/publication/38039955_Peptide_Mediated_siRNA_Delivery
Peptide Mediated siRNA Delivery. ... Sequences of Protein-Derived CPPs ... was used as a new siRNA delivery system. This peptide exhibited a high affinity for siRNA and ability to efficiently ...
https://www.ncbi.nlm.nih.gov/pubmed/23140460
siRNA-induced RNA Interference (RNAi) responses have great potential to treat human disease; however, siRNAs are highly charged macromolecules with no ability to enter cells and require a delivery agent. Peptide Transduction Domains (PTDs), also called Cell Penetrating Peptides (CPPs), are delivery peptides with the potential to deliver ...Author: Asaf Presente, Steven F. Dowdy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032848/
Dec 17, 2013 · Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA. ... and unwanted immune responses and potential safety problems that can be caused by the bacterial sequences. Furthermore, this delivery method requires transfection tools. Here we show that simple treatment with cell-penetrating peptide (CPP ...Author: Suresh Ramakrishna, Abu-Bonsrah Kwaku Dad, Jagadish Beloor, Ramu Gopalappa, Sang-Kyung Lee, Hyongbum...
https://patents.google.com/patent/WO2011020188A1/en
Peptides and a complex comprising a peptide and a cargo molecule, wherein the peptide and the cargo molecule are coupled by a non-covalent molecular association Peptides of the invention are designed according to five separate design criteria Certain members of these groups w ere found to facilitate the delivery en of siRNA molecules into eukariotic cells and siRNA mediated silencing of ...Author: Pu Chen, Jafari Mousa, John X. Jiang, Shan-Yu Fung, Hong Yong
https://www.sciencedirect.com/science/article/pii/S0169409X16302368
Functional peptides for siRNA delivery ... site-specific mutagenesis of natural peptide sequences, and computer-aided design. ... L.M. Andino, M.L. Sokolosky, A. JakymiwFusogenic-oligoarginine peptide-mediated delivery of siRNAs targeting the CIP2A oncogene into oral cancer cells. PLoS One, 8 (2013), Article e73348. Google Scholar.Author: Wanyi Tai, Xiaohu Gao
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(16)30083-X.pdf
siRNA and goes on to focus on recent advances in their peptide-mediated cell and in vivo delivery and how peptide use has influenced drug development. The review discusses the challenges associated with understanding the physiologi-cal and toxicological aspects of peptide-mediated delivery.
https://www.sciencedirect.com/science/article/pii/S1931524419301458
Schematic representation of peptide-mediated siRNA delivery strategies into cells. A, Cell-penetrating peptides (CPPs), including cationic, amphipathic, and targeting/homing peptides. B, Endosome-disrupting peptides, including fusogenic, pH-sensitive amphipathic, and proton buffering peptides. C, Multifunctional peptide complexes.Author: James C. Cummings, Haiwen Zhang, Andrew Jakymiw
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073348
Most importantly, the 599 peptide-mediated siRNA delivery promoted significant CIP2A mRNA and protein silencing which resulted in decreased oral cancer cell invasiveness and anchorage-independent growth. Together, these data demonstrate that a chimeric peptide consisting of a fusogenic sequence, in combination with cell-penetrating residues ...Author: Liliana Cantini, Christopher C. Attaway, Betsy Butler, Lourdes M. Andino, Melissa L. Sokolosky, Andr...
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