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https://www.sciencedirect.com/science/article/pii/S0169409X16302368
For siRNA delivery, an 8-arm peptide, H 3 K8b, was complexed with siRNA targeting β-galactosidase and applied to mouse endothelial cells that were stably expressing β-galactosidase. The branched peptide was capable of reducing β-galactosidase expression by 80% at a siRNA concentration of 300 nM.Author: Wanyi Tai, Xiaohu Gao
https://www.researchgate.net/publication/38039955_Peptide_Mediated_siRNA_Delivery
Peptide Mediated siRNA Delivery. ... was used as a new siRNA delivery system. This peptide exhibited a high affinity for siRNA and ability to efficiently deliver siRNA into the cells. The ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765502/
Furthermore, we expected that the degree of siRNA delivery to those cells would be dependent on the cell type and the presence of the peptide ligand. To load siRNA into the nanocarrier, lyophilized nanogels were loaded with siGLO (a fluorescently labeled siRNA delivery tracker) by reswelling them in a concentrated solution of the siRNA, as ...Author: William H. Blackburn, Erin B. Dickerson, Michael H. Smith, John F. McDonald, L. Andrew Lyon
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410048/
Apr 28, 2017 · Secondary structure was determined when peptide is free in solution, mixed with siRNA at a peptide:siRNA molar ratio of R = 20, or when liposomes are added to the peptide:siRNA mix at a lipid/peptide ratio of r = 5 (Fig. 1 a, b).Author: Anaïs Vaissière, Gudrun Aldrian, Karidia Konate, Mattias F. Lindberg, Carole Jourdan, Anthony Telmar...
https://pubs.acs.org/doi/10.1021/nn401317t
A system that permits the delivery of cargoes to the lung endothelium would be extraordinarily useful in terms of curing a wide variety of lung-related diseases. This study describes the development of a multifunctional envelope-type nanodevice (MEND) that targets the lung endothelium, delivers its encapsulated siRNA to the cytoplasm, and eradicates lung metastasis. The key to the success can ...Author: Kenji Kusumoto, Hidetaka Akita, Taichi Ishitsuka, Yu Matsumoto, Takahiro Nomoto, Ryo Furukawa, Ayman...
https://www.sciencedirect.com/science/article/pii/S0142961211005412
SiRNA delivery to target cells requires a suitable vector system as cells do not take up naked siRNA and the molecule itself is unstable . Many synthetic nanoparticle formulations used for DNA delivery have also been investigated for use with siRNA since plasmid DNA (pDNA) and siRNA delivery share many of the same challenges.Author: Aristides D. Tagalakis, Lin He, Luisa Saraiva, Kenth T. Gustafsson, Stephen L. Hart
https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-017-0269-2
Apr 28, 2017 · Small interfering RNAs (siRNAs) are powerful tools to control gene expression. However, due to their poor cellular permeability and stability, their therapeutic development requires a specific delivery system. Among them, cell-penetrating peptides (CPP) have been shown to transfer efficiently siRNA inside the cells. Recently we developed amphipathic peptides able to self-assemble with …Author: Anaïs Vaissière, Gudrun Aldrian, Karidia Konate, Mattias F. Lindberg, Carole Jourdan, Anthony Telmar...
https://iopscience.iop.org/article/10.1088/1361-6528/ab313d
Jul 29, 2019 · The use of both DOPE-PEG3.4K-bombesin targeting peptide in the formulations of the delivery system was shown to enhance the efficiency of the delivery system of siRNA for PC3 and eGFP-PC3 cells through cellular uptake and gene knockdown assays.Author: Waleed M. Hussein, Waleed M. Hussein, Yee S. Cheong, Chang Liu, Genan Liu, Anjuman Ara Begum, Maria ...
https://pubs.acs.org/doi/10.1021/mp200481g
Cell penetrating peptides (CPPs) are short strands of arginine- and/or lysine-rich peptides (<30 amino acids) that use their cationic nature for efficient intracellular accumulation. CPPs have been used for small interfering RNA (siRNA) delivery by direct complexation with the siRNA anionic phosphate backbone. During this process, however, part of the CPP cationic charges are neutralized, and ...
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(16)30083-X.pdf
siRNA and goes on to focus on recent advances in their peptide-mediated cell and in vivo delivery and how peptide use has influenced drug development. The review discusses the challenges associated with understanding the physiologi-cal and toxicological aspects of peptide-mediated delivery.
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