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https://www.researchgate.net/publication/12082085_Peptide-mediated_cellular_delivery
Peptide-mediated molecular therapeutic delivery systems have recently emerged as an alternative means to effectively substitute or augment present gene therapy technologies, e.g., TAT, VP22 ...
https://www.sciencedirect.com/science/article/abs/pii/S0169409X04002741
An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery, J. Biol. Chem. 276 (2001) 5836–5840.]. The mechanism by which the Tat peptide adheres to, and crosses, the plasma membrane of cells is currently a topic of heated discussion in the literature, with varied findings being reported.
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(16)30083-X
Peptide-mediated delivery often results in raised levels of cellular activity but it could also lead to increases in off-target effects (compare use of cationic liposomes to enhance delivery which have suffered from the same problems).
https://www.nature.com/articles/s41598-017-10870-5
Chang, J., Hoel, F., Liu, K. et al. Peptide-mediated delivery of donor mitochondria improves mitochondrial function and cell viability in human cybrid cells with the MELAS A3243G mutation.
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(16)30083-X.pdf
affect cellular processes, schematically illustrated in Figure 1. The most obvious approach, originally proposed by Zamecnik and Stevenson,13 is antisense binding through Watson-Crick base pairing to messenger RNA (mRNA) to block translational REVIEW Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA
https://www.researchgate.net/publication/10690760_Peptide-mediated_cellular_delivery_of_antisense_oligonucleotides_and_their_analogues
Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues ... a platform technology for the enhancement of cellular and in vivo delivery suitable for widespread use as ...
https://www.sciencedirect.com/science/article/pii/S0939641119300797
Peptide-mediated delivery of therapeutic mRNA in ovarian cancer. ... charge-driven interactions with a cationic or ionizable delivery agent. Following cellular uptake, induction of efficient endosomal escape is a distinctive characteristic of active delivery vectors .
https://academic.oup.com/femsle/article/215/2/267/491439
To assess peptide-mediated delivery into two yeast and three bacterial species, a range of cell penetrating and signal peptide sequences were fused to green fluorescent protein (GFP), expressed in Escherichia coli, partially purified and incubated with growing cells. Fluorescence microscopy indicated several peptides that mediated delivery.
https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201805900
Diselenolane‐Mediated Cellular Uptake: Efficient Cytosolic Delivery of Probes, Peptides, Proteins, Artificial Metalloenzymes and Protein‐Coated Quantum Dots. Dr. Eline Bartolami. National Centre of Competence in Research (NCCR) Chemical Biology, School of Chemistry and Biochemistry, University of Geneva, CH-1211 Geneva, Switzerland.
https://www.sciencedirect.com/science/article/pii/S000527360400241X
On the mechanism of non-endosomial peptide-mediated cellular delivery of nucleic acids. ... related to the ability of MPG to promote membrane permeabilization to ions and these properties can be related to the peptide-mediated translocation of the cargo through membranes. 2. Materials and methods ... Since Pep-1 favours the delivery of large ...
https://www.researchgate.net/publication/259114594_Cellular_Delivery_of_Peptide_Nucleic_Acids_PNAs
Cellular Delivery of Peptide Nucleic Acids (PNAs) Article (PDF Available) in Methods in molecular biology (Clifton, N.J.) 1050:193-205 · January 2014 with 380 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/pii/S0142961213007965
A pH-responsive α-helical cell penetrating peptide-mediated liposomal delivery system. ... initiating activated cell penetrating capacity and leading to enhanced cellular and tumor spheroid uptake. The endocytosis inhibition assay demonstrated that the endocytosis of TH-Lip was influenced by the positively charged surface of the liposomes in ...
https://www.researchgate.net/publication/8011617_Brooks_H_Lebleu_B_Vives_E_Tat_peptide-mediated_cellular_delivery_back_to_basics_Adv_Drug_Deliv_Rev_57_559-577
Brooks, H., Lebleu, B. & Vives, E. Tat peptide-mediated cellular delivery: back to basics. ... Present and future of cell-penetrating peptide mediated delivery systems: “Is the Trojan horse too ...
https://pubs.acs.org/doi/10.1021/cb600127m
Cell penetrating peptide mediated quantum dot delivery and release in live mammalian cells. 2014,,, 4260-4263. DOI: 10.1109/EMBC.2014.6944565. Alfredo Erazo-Oliveras, Kristina Najjar, Laila Dayani, Ting-Yi Wang, Gregory A Johnson, Jean-Philippe Pellois. Protein delivery into live cells by incubation with an endosomolytic agent.
https://www.sciencedirect.com/science/article/pii/S2162253119303051
Peptide ligands can enhance delivery of nucleic acid-loaded nanoparticles to tumors by promoting their cell binding and internalization. Lung tumor lesions accessible from the alveolar side can be transfected, in principle, using gene vectors delivered as an aerosol.
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