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https://www.researchgate.net/publication/10690760_Peptide-mediated_cellular_delivery_of_antisense_oligonucleotides_and_their_analogues
Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues Article · Literature Review (PDF Available) in Cellular and Molecular Life Sciences CMLS 60(5):844-53 · June ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390225/
Jun 12, 2012 · Strategies For Peptide-Mediated Delivery. There are two main ways of utilizing peptide vectors for the delivery of antisense oligonucleotides and siRNA. The first method involves chemical synthesis of peptides that are modified to enable covalent conjugation to oligonucleotides or other cargo types (Figure 3a). Such conjugation reactions may be ...Author: Peter Järver, Thibault Coursindel, Samir El Andaloussi, Samir El Andaloussi, Caroline Godfrey, Matth...
https://www.cell.com/molecular-therapy-family/nucleic-acids/pdf/S2162-2531(16)30083-X.pdf
affect cellular processes, schematically illustrated in Figure 1. The most obvious approach, originally proposed by Zamecnik and Stevenson,13 is antisense binding through Watson-Crick base pairing to messenger RNA (mRNA) to block translational REVIEW Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(16)30083-X
Jan 01, 2012 · Antisense oligonucleotides and short interfering RNAs (siRNAs) are nucleic acids-targeting reagents for gene expression modulation that are being developed as drugs for many applications. A number of useful synthetic nucleic acids analogues have been introduced recently to greatly improve their properties for use as therapeutics. However, their full effectiveness in cells and in …Author: Peter Järver, Thibault Coursindel, Samir El Andaloussi, Samir El Andaloussi, Caroline Godfrey, Matth...
https://www.researchgate.net/publication/235366775_Peptide-mediated_Cell_and_In_Vivo_Delivery_of_Antisense_Oligonucleotides_and_siRNA
This review begins by describing the modes of action of antisense reagents and siRNA and goes on to focus on recent advances in their peptide-mediated cell and in vivo delivery and how peptide use ...
https://link.springer.com/protocol/10.1385%2F1-59259-823-4%3A205
Methods of peptide-oligonucleotide conjugate synthesis are presented that may be useful in the study of cell targeting and delivery of oligonucleotides and their analogs. The first method involves total stepwise solid-phase synthesis on a single support.Author: Dmitry A. Stetsenko, Michael J. Gait
https://www.sciencedirect.com/science/article/pii/S0014483504001794
Inhibition of in vitro VEGF expression and choroidal neovascularization by synthetic dendrimer peptide mediated delivery of a sense oligonucleotide. ... M.J. GaitPeptide-mediated cellular delivery of antisense oligonucleotides and their analogues. Cell. Mol. Life Sci., 60 (2003), pp. 844-853.Author: Robert J. Marano, Norbert Wimmer, Philip S. Kearns, Bradley G. Thomas, Istvan Toth, Meliha Brankov, ...
https://www.nature.com/articles/7700931
Jan 20, 2006 · Local delivery of c-myc neutrally charged antisense oligonucleotides with transport catheter inhibits myointimal hyperplasia and positively affects vascular remodeling in …Author: G R Devi
https://www.sciencedirect.com/science/article/pii/S0169409X00000806
Oct 31, 2000 · Antisense oligonucleotides, ribozymes and DNAzymes have emerged as novel, highly selective inhibitors or modulators of gene expression. Indeed, their use in the treatment of diseases arising from genetic abnormalities has become a real possibility over the past few years.Author: Saghir Akhtar, Marcus D. Hughes, Marcus D. Hughes, Alim Khan, Alim Khan, Mike Bibby, Majad Hussain, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778081/
The focus of this article is recent progress in the field of peptide-mediated cellular delivery of siRNA and steric block oligonucleotides in cell tissue culture as a starting point for further developments illustrated by own experimental data.Author: S.D Laufer, T Restle
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